110642-42-7

• 常用中文名：(E)-5-Hydroxyferulic acid
• 常用英文名：(E)-5-Hydroxyferulic acid
• CAS号：110642-42-7
• 分子式：C₁₀H₁₀O₅
• 分子量：210.18300
• 相关类别： 信号通路 代谢酶/蛋白酶 COMT
• 发布时间：2016-03-25 03:41:49
• 更新时间：2025-08-27 10:04:44
• (E) 5-H-羟基阿魏酸是5-羟基阿魏酸(HY-133068)的E异构体。5-羟基阿魏酸是一种羟基肉桂酸,是苯丙醇途径的代谢产物。5-羟基阿魏酸是芥酸生物合成的前体,也是COMT非酯化底物[1][2][3]。

名称

• 英文名: 3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoic acid
• 英文别名: 2-Propenoic acid,3-(3,4-dihydroxy-5-methoxyphenyl)-,(2E); p-hydroxyferulic acid; 5-hydroxyferulic acid; (E)-3,4-dihydroxy-5-methoxycinnamic acid; (E)-5-hydroxyferulic acid; 4,5-Dihydroxy-3-methoxy-zimtsaeure (3-Methoxy-kaffeesaeure)

物化性质

• 分子式: C₁₀H₁₀O₅
• 分子量: 210.18300
• 精确质量: 210.05300
• PSA: 86.99000
• LogP: 1.20420

生物活性

• 描述: (E) 5-H-羟基阿魏酸是5-羟基阿魏酸(HY-133068)的E异构体。5-羟基阿魏酸是一种羟基肉桂酸,是苯丙醇途径的代谢产物。5-羟基阿魏酸是芥酸生物合成的前体,也是COMT非酯化底物[1][2][3]。
• 相关类别:
  信号通路 >> 神经信号通路 >> COMT
  研究领域 >> 代谢疾病
  信号通路 >> 代谢酶/蛋白酶 >> COMT
• 参考文献:

  [1]. Parvathi K, et al. Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols. Plant J. 2001 Jan;25(2):193-202.

  [2]. Maury S, et al. Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase classes have distinct substrate specificities and expression patterns. Plant Physiol. 1999 Sep;121(1):215-24.

  [3]. Inoue K, et al. Substrate preferences of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferases in developing stems of alfalfa (Medicago sativa L.). Arch Biochem Biophys. 2000 Mar 1;375(1):175-82.

合成路线

141-82-2 3934-87-0 ~64% 110642-42-7

文献：Lam; Iiyama; Stone Phytochemistry, 1996 , vol. 41, # 6 p. 1507 - 1510

2973-76-4 ~% 110642-42-7

文献：Lam; Iiyama; Stone Phytochemistry, 1996 , vol. 41, # 6 p. 1507 - 1510

121-33-5 ~% 110642-42-7

文献：Lam; Iiyama; Stone Phytochemistry, 1996 , vol. 41, # 6 p. 1507 - 1510

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