110642-42-7

110642-42-7 structure

Name: (E)-5-Hydroxyferulic acid
Chemical Name: 3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoic acid
CAS Number: 110642-42-7
Molecular Formula: C₁₀H₁₀O₅
Molecular Weight: 210.18300
Catalog: Signaling Pathways Metabolic Enzyme/Protease COMT
Create Date: 2016-03-25 03:41:49
Modify Date: 2025-08-27 10:04:44
(E)-5-Hydroxyferulic acid is the E-isomer of 5-hydroxyferulic acid (HY-133068). 5-hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrat[1][2][3].

Name	3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoic acid
Synonyms	2-Propenoic acid,3-(3,4-dihydroxy-5-methoxyphenyl)-,(2E) p-hydroxyferulic acid 5-hydroxyferulic acid (E)-3,4-dihydroxy-5-methoxycinnamic acid (E)-5-hydroxyferulic acid 4,5-Dihydroxy-3-methoxy-zimtsaeure (3-Methoxy-kaffeesaeure)

Description	(E)-5-Hydroxyferulic acid is the E-isomer of 5-hydroxyferulic acid (HY-133068). 5-hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrat[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> COMT Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> COMT
References	[1]. Parvathi K, et al. Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols. Plant J. 2001 Jan;25(2):193-202. [2]. Maury S, et al. Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase classes have distinct substrate specificities and expression patterns. Plant Physiol. 1999 Sep;121(1):215-24. [3]. Inoue K, et al. Substrate preferences of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferases in developing stems of alfalfa (Medicago sativa L.). Arch Biochem Biophys. 2000 Mar 1;375(1):175-82.

141-82-2

3934-87-0

~64%

110642-42-7

Literature: Lam; Iiyama; Stone Phytochemistry, 1996 , vol. 41, # 6 p. 1507 - 1510

2973-76-4

110642-42-7

Literature: Lam; Iiyama; Stone Phytochemistry, 1996 , vol. 41, # 6 p. 1507 - 1510

121-33-5

110642-42-7

Literature: Lam; Iiyama; Stone Phytochemistry, 1996 , vol. 41, # 6 p. 1507 - 1510

Precursor 4
141-82-2 3934-87-0 2973-76-4 121-33-5
DownStream 0