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5870-29-1生产厂家

5870-29-1价格

5870-29-1

5870-29-1结构式
5870-29-1结构式
  • 常用中文名:盐酸环喷托酯
  • 常用英文名:Cyclopentolate Hydrochloride
  • CAS号:5870-29-1
  • 分子式:C17H26ClNO3
  • 分子量:327.84600
  • 相关类别: 分析化学 标准品 法医和兽医标准品
  • 发布时间:2018-07-02 19:05:36
  • 更新时间:2024-01-08 12:41:05
  • Cyclopentolate (DL-Cyclopentolate) hydrochloride 是眼科常用的抗毒蕈碱药物。Cyclopentolate hydrochloride 是一种阿托品样毒蕈碱受体 (muscarinic receptor) 拮抗剂,对睫状肌毒蕈碱受体的 pKB 值为 7.8。

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中文名 盐酸环喷托酯
英文名 Cyclopentolate Hydrochloride
中文别名 环戊通
英文别名 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate,hydrochloride
描述 Cyclopentolate (DL-Cyclopentolate) hydrochloride 是眼科常用的抗毒蕈碱药物。Cyclopentolate hydrochloride 是一种阿托品样毒蕈碱受体 (muscarinic receptor) 拮抗剂,对睫状肌毒蕈碱受体的 pKB 值为 7.8。
相关类别
体内研究 环戊酯(20 mg/kg)预处理大鼠的存活率为90%[3]。动物模型:80只Sprague-Dawley大鼠(急性、致死性有机磷农药(OP)中毒模型)[3]剂量:20 mg/kg(眼用环戊酸钠)给药:i.p.结果:经眼用环戊酸钠(20 mg/kg)预处理的大鼠存活率为90%。
参考文献

[1]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928.

[2]. Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998;14(4):363‐373.

[3]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928.

沸点 409.7ºC at 760mmHg
熔点 137-141°
分子式 C17H26ClNO3
分子量 327.84600
闪点 201.5ºC
精确质量 327.16000
PSA 49.77000
LogP 2.98210
储存条件 −20°C
水溶解性 Very soluble in water, freely soluble in ethanol (96 per cent). It shows polymorphism (5.9).

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GY2450000
CHEMICAL NAME :
Cyclopentaneacetic acid, 1-hydroxy-alpha-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER :
5870-29-1
LAST UPDATED :
199806
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C17-H25-N-O3.Cl-H
MOLECULAR WEIGHT :
327.89
WISWESSER LINE NOTATION :
L5TJ AYR&VO2N1&1 AQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
40 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 87,634,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Ocular
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
50 ug/kg/I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 105,91,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2235 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,444,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,141,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
292 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,444,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,516,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2737 No. of Facilities: 112 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 3472 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2737 No. of Facilities: 131 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 2009 (estimated) No. of Female Employees: 1464 (estimated)

危害码 (欧洲) Xi
危险品运输编码 NONH for all modes of transport
WGK德国 2
RTECS号 GY2450000
海关编码 2922509090
海关编码 2922509090
中文概述 2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件 A.入境货物通关单 B.出境货物通关单
检验检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%