18865-48-0

• 常用中文名：放线菌素V
• 常用英文名：Actinomycin X2
• CAS号：18865-48-0
• 分子式：C₆₂H₈₄N₁₂O₁₇
• 分子量：1269.40000
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-09-13 10:46:27
• 更新时间：2025-08-25 17:41:52
• Actinomycin X2 (Actinomycin V) 是由许多链霉菌属物种产生的,对 MRSA 表现出强烈的抑制作用,最小抑菌浓度 (MIC) 值为 0.25 μg/mL。Actinomycin X2 可用于癌症和细菌感染。

名称

• 中文名: 放线菌素V
• 英文名: actinomycin v
• 英文别名: 5'-Deoxy(Methylthio-d3)adenosine; 3h-phenoxazine,actinomycindderiv.; [A3-(4-oxo-L-proline)]-actinomycin-D; 5'-S-(Methyl-d3)thioadenosine; 3a-(4-oxo-l-proline)-actinomycin; 5'-(Methylthio-d3)adenosine; actinomycin-V; ACTINOMYCIN X2

物化性质

• 密度: 1.44g/cm3
• 沸点: 1411.4ºC at 760mmHg
• 分子式: C₆₂H₈₄N₁₂O₁₇
• 分子量: 1269.40000
• 闪点: 807.4ºC
• 精确质量: 1268.61000
• PSA: 377.05000
• LogP: 1.55260
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.661

生物活性

• 描述: Actinomycin X2 (Actinomycin V) 是由许多链霉菌属物种产生的,对 MRSA 表现出强烈的抑制作用,最小抑菌浓度 (MIC) 值为 0.25 μg/mL。Actinomycin X2 可用于癌症和细菌感染。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AU2010000 CHEMICAL NAME : Actinomycin X2 CAS REGISTRY NUMBER : 18865-48-0 LAST UPDATED : 199706 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C62-H84-N12-O17 MOLECULAR WEIGHT : 1269.58 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1625,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,427,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),48,1980

安全

• 危害码 (欧洲): T+: Very toxic;
• 风险声明 (欧洲): 26/27/28-63
• 安全声明 (欧洲): 22-36/37/39-45
• 危险品运输编码: UN 2811 6.1/PG 2