504-24-5

504-24-5结构式

常用中文名：4-氨基吡啶
常用英文名：4-AMINOPYRIDINE
CAS号：504-24-5
分子式：C₅H₆N₂
分子量：94.115
相关类别：医药中间体杂环化合物吡啶类化合物氨基吡啶
发布时间：2018-08-04 18:20:48
更新时间：2024-01-03 00:27:23
4-Aminopyridine是非选择性钾离子通道阻断剂,能从细胞质侧与靶点结合。

中文名	4-氨基吡啶
英文名	4-aminopyridine
中文别名	4-胺吡啶鸟安定氨吡啶
英文别名	pyridin-4-amine T6NJ DZ Neurelan p-amino pyridine Ampydin 4APY 4-Aminopyridine EINECS 207-987-9 p-Aminopyridine [UN2671] [Poison] Ampyra 4-pyridylamine 5-22-09-00106 (Beilstein Handbook Reference) Dalfampridine EL 970 Pyridine, 4-amino- vmi10-3 Prc 1237 Pyridin-4-amin Fampridine 4-pyridinylamine 4-AP mi-w-3 Pymadin avitrol pyridin-4-yl-amine MFCD00006439 4-Pyridinamine pyridine-4-amine 4-amino-pyridine 4-AMINO PYRIDINE

描述	4-Aminopyridine是非选择性钾离子通道阻断剂,能从细胞质侧与靶点结合。
相关类别	信号通路 >> 跨膜转运 >> 钾通道研究领域 >> 其他
参考文献	[1]. Sherratt, R.M., H. Bostock, and T.A. Sears, Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres. Nature, 1980. 283(5747): p. 570-2. [2]. Bouchard, R. and D. Fedida, Closed- and open-state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J Pharmacol Exp Ther, 1995. 275(2): p. 864-76.

密度	1.1±0.1 g/cm3
沸点	192.7±40.0 °C at 760 mmHg
熔点	157 °C
分子式	C₅H₆N₂
分子量	94.115
闪点	70.3±27.3 °C
精确质量	94.053101
PSA	38.91000
LogP	-2.24
外观性状	白色至淡黄色晶体
蒸汽压	0.5±0.4 mmHg at 25°C
折射率	1.569
储存条件	储存注意事项储存于阴凉、通风良好的专用库房内，实行“双人收发、双人保管”制度。远离火种、热源。包装密封。应与氧化剂、酸类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
稳定性	1.稳定性稳定 2.禁配物强氧化剂、强酸类 3.避免接触的条件受热 4.聚合危害不聚合
分子结构	1、摩尔折射率：28.58 2、摩尔体积（cm³/mol）：84.9 3、等张比容（90.2K）：227.2 4、表面张力（dyne/cm）：51.2 5、极化率（10-24cm3）：11.33
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:2 4.可旋转化学键数量:0 5.互变异构体数量:2 6.拓扑分子极性表面积38.9 7.重原子数量:7 8.表面电荷:0 9.复杂度:48 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：无色针状结晶 2.熔点（℃）：155~158 3.沸点（℃）：273 4.饱和蒸气压（kPa）：1.73（180℃） 5.辛醇/水分配系数：0.25 6.闪点（℃）：164 7.溶解性：溶于水、乙醚、苯，易溶于乙醇。

国标编号:	61842
ＣＡＳ:	504-24-5
中文名称:	4-氨基吡啶
英文名称:	4-Aminopyridine；Υ-Pyridylamine
别名:	Υ-吡啶胺；对氨基吡啶
分子式:	C₅H₆N₂；NC₅H₄NH₂
分子量:	94.12
熔点:	158～159℃ 沸点：273
密度:
蒸汽压:	1.73kPa(180℃)
溶解性:	溶于水、乙醚、苯，易溶于乙醇
稳定性:	稳定
外观与性状:	无色针状结晶
危险标记:	14(毒害品)
用途:	用于有机合成及制药工业

2.对环境的影响:

一、健康危害

侵入途径：吸入、食入、经皮吸收。健康危害：对眼睛、皮肤、粘膜和上呼吸道有刺激性。高浓度摄入可引起呼吸衰竭、致死。

二、毒理学资料及环境行为

毒性：属高毒类。急性毒性：LD5020mg/kg(大鼠经口)

危险特性：遇明火、高热可燃。与强氧化剂可发生反应。受热分解放出有毒的氧化氮烟气。燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。

3.现场应急监测方法:

4.实验室监测方法:

环境水和底质样品中2-和4-氨基吡喧的测定[刊，日]/Hattori Y.；Sugimae A.，Kuge Y.—//日本化学会社.-1984，(12).-1895～1900《分析化学文摘》1986.11

5.环境标准:

美国车间卫生标准 2mg/m3(2-氨基吡啶)

6.应急处理处置方法:

一、泄漏应急处理

隔离泄漏污染区，周围设警告标志。建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物。避免扬尘，小心扫起，置于袋中转移至安全场所。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，用收集回收或无害处理后废弃。

二、防护措施

呼吸系统防护：高浓度环境中，必须佩戴防毒面具。紧急事态抢救或逃生时，建设佩戴自给式呼吸器。眼睛防护：戴化学安全防护眼镜。防护服：穿相应的防护服。手防护：戴防化学品手套。其它：工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。工作服不要带到非作业场所，单独存放被毒物污染的衣服，洗后再用。保持良好的卫生习惯。

三、急救措施

皮肤接触：脱去污染的衣着，用大量流动清水彻底冲洗。注意手、足和指甲等部位。眼睛接触：立即提起眼睑，用大量流动清水或生理盐水冲洗至少15分钟。吸入：迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。食入：误服者立即漱口，给饮大量温水，催吐。就医。

灭火方法：干粉、泡沫、二氧化碳、砂土。

毒理学数据:

1.急性毒性

LD50：21mg/kg（大鼠经口）；19mg/kg（小鼠经口）

2.刺激性暂无资料

生态学数据:

1.生态毒性

LC50：2.8~7.5mg/L（96h）（蓝鳃太阳鱼）

EC50：23.6~26.5mg/L（细菌）

2.生物降解性暂无资料

3.非生物降解性空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期19h（理论）。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US1750000

CHEMICAL NAME :: Pyridine, 4-amino-

CAS REGISTRY NUMBER :: 504-24-5

BEILSTEIN REFERENCE NO. :: 0105782

LAST UPDATED :: 199710

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C5-H6-N2

MOLECULAR WEIGHT :: 94.13

WISWESSER LINE NOTATION :: T6NJ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 590 ug/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting

REFERENCE :: CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 16,487,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 120 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 32,583,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.5- 1985- Volume(issue)/page/year: 6(3),175,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,532,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 11,162,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(9-10),64,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,296,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 226,163,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 36,365,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,532,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 11,162,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JWMAA9 Journal of Wildlife Management. (Wildlife Soc., 5410 Grosvenor Lane, Bethesda, MD 20814) V.1- 1937- Volume(issue)/page/year: 29,830,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 7650 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911- Volume(issue)/page/year: (680),157,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 4200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 2370 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911- Volume(issue)/page/year: (680),157,1979 *** REVIEWS *** TOXICOLOGY REVIEW TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,532,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4032 No. of Facilities: 452 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4618 (estimated)

符号	GHS06
信号词	Danger
危害声明	H300-H315-H319-H335
警示性声明	P261-P264-P301 + P310-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T+:Verytoxic;
风险声明 (欧洲)	R28;R36/37/38
安全声明 (欧洲)	S26-S36/37/39-S45-S60-S61-S37/39-S28A-S1
危险品运输编码	UN 2671 6.1/PG 2
WGK德国	3
RTECS号	US1750000
包装等级	II
危险类别	6.1
海关编码	2933399090

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将吡啶用过氧化氢氧化，加苯酐成酞酸盐后，用稀盐酸分解制成N-氧化吡啶盐酸盐。N-氧化吡啶盐酸盐经硝化制得N-氧化-4-硝基吡啶。N-氧化-4-硝基吡啶经铁粉还原而得4-氨基吡啶。将1gN-氧化-4-硝基吡啶（熔点159℃）溶于30ml乙酸中，加入2.2g铁粉，反应随即开始，加完后于100%保温1h，放冷。加入约50ml水稀释后，用30%氢氧化钠溶液中和并调成强碱性，用乙醚提取3次，每次100ml。合并乙醚提取液，用无水碳酸钾干燥。蒸除乙醚后，减压蒸馏得4-氨基吡啶粗品。将粗品从苯或甲苯-石油醚混合溶剂中重结晶，可得0.6g白色针状结晶4-氨基吡啶，产率90%。

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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