1221485-83-1

• 常用中文名：Skepinone-L
• 常用英文名：Skepinone-L
• CAS号：1221485-83-1
• 分子式：C₂₄H₂₁F₂NO₄
• 分子量：425.425
• 相关类别： 生物化工 抑制剂 丝裂原活化蛋白激酶(MAPK) p38 MAPK 抑制剂
• 发布时间：2018-12-27 16:09:21
• 更新时间：2025-08-22 13:35:50
• Skepinone-L是选择性p38 MAPK抑制剂。

名称

• 中文名: Skepinone-L
• 英文名: 3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
• 英文别名: Skepinone-L; Skepinone-L|; 3que; 5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-; CS-0941; 2-(2,4-difluorophenylamino)-7-[2R,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]cyclohepten-5-one; X5940; S7214; 2-(2,4-Difluorophenylamino)-7-[2R-,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one; 2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one; 2-(2,4-difluoroanilino)-7-[2-(R)-3-dihydroxypropoxy]-10,11-dihydrodibenzo[a,d]cyclohepten-5-one

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 629.0±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₁F₂NO₄
• 分子量: 425.425
• 闪点: 334.2±31.5 °C
• 精确质量: 425.143860
• PSA: 78.79000
• LogP: 4.95
• 外观性状: 粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.646
• 储存条件: -20℃

生物活性

• 描述: Skepinone-L是选择性p38 MAPK抑制剂。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Koeberle, Solveigh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nature Chemical Biology (2012), 8(2), 141-143.

  [2]. Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal Chemistry (2012), 55(12), 5868-5877.

合成路线

1353948-60-3 ~97% 1221485-83-1

文献：Laufer, Stefan; Albrecht, Wolfgang Patent: US2012/115862 A1, 2012 ; Location in patent: Page/Page column 21 ;