1476-52-4

• 常用中文名：去乙基氯喹
• 常用英文名：Desethyl Chloroquine
• CAS号：1476-52-4
• 分子式：C₁₆H₂₂ClN₃
• 分子量：291.81900
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2019-02-05 17:40:41
• 更新时间：2026-07-07 15:20:34
• Desethyl chloroquine 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine 具有抗疟原虫活性。

名称

• 中文名: N4-(7-氯喹啉-4-基)-N1-乙基-1,4-戊二胺
• 英文名: Desethyl Chloroquine
• 中文别名: 去乙基羟氯喹HBR; 去乙基氯喹DIHBR(硫酸羟氯喹杂质D DIHBR); 硫酸羟基氯喹杂质D; 脱乙基氯喹DIHBR(硫酸羟氯喹杂质D DIHBR); 羟氯喹杂质9 2HBR; 去乙基硫酸羟氯喹; 硫酸羟氯喹杂质D; 硫酸羟氯喹杂质D二溴化氢(二溴去乙基氯喹); 硫酸羟基氯喹杂质4硫酸盐(硫酸羟基氯喹杂质D硫酸盐); 去乙基氯喹HBR; 氯喹相关物质D; N4-(7-氯喹啉-4-基)-N1-乙基戊烷-1,4-二胺; 脱乙基氯喹; 去乙基哌拉西林; 羟氯喹杂质D; 去乙基氯喹-D4; 羟氯喹硫酸杂质D DIHBR; 羟基氯喹杂质D-D5二盐酸; 硫酸羟基氯喹杂质4(硫酸羟基氯喹杂质D); 羟基氯喹杂质D; 去乙基氯喹 氢溴酸盐; 硫酸羟氯喹D; 硫酸羟基氯喹杂质4; 硫酸羟氯喹杂质D (去乙基氯喹)"; 氯喹杂质1(脱乙基氯喹); 硫酸羟基氯喹杂质D HBR
• 英文别名: Hydroxychloroquine Sulfate Impurity D (Chloroquine Related Compound D, Desethyl Chloroquine); Hydroxychloroquine Impurity 9 2HBr; 4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine; 4-[[1-Methyl-4-(ethylamino)butyl]amino]-7-chloroquinoline; N4-(7-chloroquinolin-4-yl)-N1-ethyl-pentane-1,4-diamine; Desethyl Chloroquine HBr (Hydroxychloroquine Sulfate Impurity D HBr); Chloroquine Related Compound-D; Chloroquine RC D; N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine; 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline,Monodesethylchloroqu​ine; N'-(7-Chloroquinolin-4-yl)-N-ethyl-1,4-pentanediamine; DESETHYL CHLOROQUINE; Chloroquine Impurity 1（Desethyl Chloroquine）; Hydroxychloroquine Sulfate Impurity D DiHBr; 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline; (4RS)-N4-(7-Chloroquinolin-4-yl)-N1-ethylpentane-1,4-diamine; 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl; N-[4-(Ethylamino)-1-methylbutyl]-7-chloroquinoline-4-amine; Hydroxychloroquine Sulfate Impurity 4（Hydroxychloroquine Sulfate Impurity D）; Monodeethylchloroquine; Chloroquine Related Compound D; Desethyl Chloroquine sulfate; Chloroquine Related Compound D (7-Chloro-4-{[4-(ethylamino)-1-methylbutyl] amino} quinoline); Hydroxy Chloroquine Impurity-D; Chloroquine Related CoMpound D; Monodesethylchloroquine; Clavulanate Potassium Impurity 20 Monomer; Desethyl Chloroquine (Hydroxychloroquine Impurity D); Hydroxychloroquine Impurity D/Desethyl Chloroquine; Deethylchloroquine; N-[1-Methyl-4-(ethylamino)butyl]7-chloro-4-quinolinamine; Desethyl Chloroquine DiHBr (Hydroxychloroquine Sulfate Impurity D DiHBr); Hydroxychloroquine Sulfate Impurity D (Desethyl Chloroquine); (7-chloro-4-quinolyl)-[4-(ethylamino)-1-methyl-butyl]amine

物化性质

• 密度: 1.138g/cm3
• 沸点: 451.7ºC at 760mmHg
• 熔点: 94-97?C
• 分子式: C₁₆H₂₂ClN₃
• 分子量: 291.81900
• 闪点: 227ºC
• 精确质量: 291.15000
• PSA: 36.95000
• LogP: 4.54220
• 蒸汽压: 2.38E-08mmHg at 25°C
• 折射率: 1.602
• 储存条件: -20°C Freezer

生物活性

• 描述: Desethyl chloroquine 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine 具有抗疟原虫活性。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 感染
  信号通路 >> 自噬 >> 自噬
• 体外研究: P、 恶性肿瘤[1]
• 体内研究: 对野生型和亨廷顿病(Q175/Q175)小鼠腹腔注射氯喹。LC-MS/MS用于比较血液、大脑和肌肉组织中氯喹及其代谢物的含量。氯喹的浓度较低(5-15M),但与上次给药后4-24小时内的血液或肌肉相比,在脑组织中更稳定。注射后24小时内,肌肉和血液中的活性氯喹代谢物地乙基氯喹水平降低,而大脑地乙基氯喹水平较低,在同一时间段内略有上升[3]。
• 参考文献:

  [1]. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.

  [2]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.

  [3]. Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933499090

合成路线

75-04-7 ~% 1476-52-4

文献：Journal of the American Chemical Society, , vol. 68, p. 1224

54-05-7 ~% 1476-52-4

文献：European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

86-98-6 ~% 1476-52-4

文献：Journal of the American Chemical Society, , vol. 68, p. 1224

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海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%