550-83-4

• 常用中文名：盐酸丙氧卡因
• 常用英文名：Propoxycaine (hydrochloride)
• CAS号：550-83-4
• 分子式：C₁₆H₂₇ClN₂O₃
• 分子量：330.85000
• 相关类别： 信号通路 跨膜转运 钠通道
• 发布时间：2017-10-09 22:15:48
• 更新时间：2024-01-11 16:13:39
• Propoxycaine盐酸盐是一种局部麻醉剂, 结合并抑制电压门控钠通道, 抑制脉冲起始和传导所需的离子通量, 从而导致感觉的丢失。

名称

• 中文名: 盐酸丙氧卡因
• 英文名: 2-(diethylamino)ethyl 4-amino-2-propoxybenzoate,hydrochloride
• 英文别名: Pravocaine hydrochloride; EINECS 208-988-7; WIN 3459; Propoxycaine HCl; Ravocaine hydrochloride; Blockain; 4-Amino-2-propoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride; BENZOIC ACID,4-AMINO-2-PROPOXY-,2-(DIETHYLAMINO)ETHYL ESTER,MONOHYDROCHLORIDE; Propoxycaine Hyrochloride; Propoxycaine hydrochloride; Propoxycaine (hydrochloride)

物化性质

• 沸点: 434.4ºC at 760mmHg
• 分子式: C₁₆H₂₇ClN₂O₃
• 分子量: 330.85000
• 闪点: 216.5ºC
• 精确质量: 330.17100
• PSA: 64.79000
• LogP: 3.93940
• 储存条件: 2-8℃

生物活性

• 描述: Propoxycaine盐酸盐是一种局部麻醉剂, 结合并抑制电压门控钠通道, 抑制脉冲起始和传导所需的离子通量, 从而导致感觉的丢失。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DG3066000 CHEMICAL NAME : Benzoic acid, 4-amino-2-propoxy-, 2-(diethylamino)ethyl ester, monohydrochloride CAS REGISTRY NUMBER : 550-83-4 LAST UPDATED : 199709 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C16-H26-N2-O3.Cl-H MOLECULAR WEIGHT : 330.90 WISWESSER LINE NOTATION : 3OR CZ FVO2N2&2 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7417 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958

安全

• 危险品运输编码: UN 2811 6.1 / PGIII