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4-苯胺-1-羟基苯

4-苯胺-1-羟基苯用途

LY83583是可溶性鸟苷酸环化酶(sGC)的一种细胞通透性和竞争性抑制剂,IC50值为2µM[1]。

4-苯胺-1-羟基苯名称

[ CAS 号 ]:
91300-60-6

[ 中文名 ]:
4-苯胺-1-羟基苯

[ 英文名 ]:
LY83583

[英文别名 ]:

6-anilinoquinoline-5,8-dione
6-(Phenylamino)quinoline-5,8-dione
5,8-Quinolinedione, 6-(phenylamino)-
6-ANILINO-5,8-QUINOLINEDIONE
MFCD00210756

4-苯胺-1-羟基苯生物活性

[ 描述 ]:

LY83583是可溶性鸟苷酸环化酶(sGC)的一种细胞通透性和竞争性抑制剂,IC50值为2µM[1]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 鸟苷酸环化酶

[参考文献]

[1]. Mülsch A, et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25.

4-苯胺-1-羟基苯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
446.9±45.0 °C at 760 mmHg

[ 熔点 ]:
184-185°C

[ 分子式 ]:
C₁₅H₁₀N₂O₂

[ 分子量 ]:
250.252

[ 闪点 ]:
224.1±28.7 °C

[ 精确质量 ]:
250.074234

[ PSA ]:
59.06000

[ LogP ]:
1.56

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.715

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
0.1 M HCl: 1 mg/mL

4-苯胺-1-羟基苯安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ 海关编码 ]:
2933499090

4-苯胺-1-羟基苯合成路线

详细合成路线

4-苯胺-1-羟基苯上下游产品

4-苯胺-1-羟基苯上游产品

4-苯胺-1-羟基苯下游产品

4-苯胺-1-羟基苯海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-苯胺-1-羟基苯文献

Nitric oxide donors reduce the invasion ability of ovarian cancer cells in vitro.

Anticancer Drugs 25(10) , 1141-51, (2014)

The most important factors involved in tumor metastasis and angiogenesis are metalloproteinases (MMPs), vascular endothelial growth factor, and multifunctional transforming growth factor β1. These fac...

Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.

Plant Mol. Biol. 81(1-2) , 27-40, (2013)

Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone ...

Comparative study of the quercetin, ascorbic acid, glutathione and superoxide dismutase for nitric oxide protecting effects in mouse gastric fundus.

Eur. J. Pharmacol. 698(1-3) , 379-87, (2013)

The aim of this work was to compare the preventing capacity of quercetin with Cu/Zn superoxide dismutase (Cu/Zn SOD), ascorbic acid and glutathione on nitric oxide (NO)-induced relaxation in mouse gas...

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