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核糖核酸酶H

核糖核酸酶H用途

来自大肠杆菌的核糖核酸酶H已被用于评估镁离子的金属生物化学。核糖核酸酶H还被用于研究HIV-1逆转录酶相关Rnase H活性的选择性抑制剂。

核糖核酸酶H名称

[ CAS 号 ]:
9050-76-4

[ 中文名 ]:
核糖核酸酶H

[ 英文名 ]:
Ribonuclease H, from Escherichia coli

[英文别名 ]:

MFCD00132186

核糖核酸酶H生物活性

[ 描述 ]:

核糖核酸酶H是一种降解DNA-RNA杂交体RNA部分的酶[1]。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 其他

[参考文献]

[1]. Hausen P, et al. Ribonuclease H. An enzyme degrading the RNA moiety of DNA-RNA hybrids. Eur J Biochem. 1970 Jun;14(2):278-83.

核糖核酸酶H物理化学性质

[ 外观性状 ]:
液体

[ 储存条件 ]:
−20°C

核糖核酸酶H安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

核糖核酸酶H文献

Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.

Clin. Infect. Dis. 55(5) , 737-45, (2012)

It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line antiretroviral therapy (ART) in subtype C human immunod...

Metallobiochemistry of the magnesium ion. Characterization of the essential metal-binding site in Escherichia coli ribonuclease H.

Eur. J. Biochem. 219 , 253-60, (1994)

Ribonuclease H (Escherichia coli) contains one strong magnesium-binding site, as determined by metal-titration experiments monitored by high field 1H-NMR and also by direct titration calorimetry. Kine...

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

Bioorg. Med. Chem. Lett. 22(12) , 3988-92, (2012)

We report herein the synthesis of a series of 3-hydroxyquinolin-2(1H)-one derivatives. Esters and amide groups were introduced at position 4 of the basis scaffold and some modulations of the benzenic ...

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