核糖核酸酶H

更新时间:2024-01-12 02:19:45

核糖核酸酶H结构式
核糖核酸酶H结构式
品牌特惠专场
常用名 核糖核酸酶H 英文名 Ribonuclease H, from Escherichia coli
CAS号 9050-76-4 分子量 N/A
密度 N/A 沸点 N/A
分子式 N/A 熔点 N/A
MSDS 美版 闪点 N/A

 核糖核酸酶H用途


来自大肠杆菌的核糖核酸酶H已被用于评估镁离子的金属生物化学。 核糖核酸酶H还被用于研究HIV-1逆转录酶相关Rnase H活性的选择性抑制剂。

 核糖核酸酶H名称

中文名 核糖核酸酶H
英文名 RIBONUCLEASE H
英文别名 更多

 核糖核酸酶H生物活性

描述 核糖核酸酶H是一种降解DNA-RNA杂交体RNA部分的酶[1]。
相关类别
参考文献

[1]. Hausen P, et al. Ribonuclease H. An enzyme degrading the RNA moiety of DNA-RNA hybrids. Eur J Biochem. 1970 Jun;14(2):278-83.  

 核糖核酸酶H物理化学性质

外观性状 液体
储存条件 −20°C

 核糖核酸酶H安全信息

危险品运输编码 NONH for all modes of transport
WGK德国 1

 核糖核酸酶H文献3

更多文献
Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.

Clin. Infect. Dis. 55(5) , 737-45, (2012)

It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line antiretroviral therapy (ART) in subtype C human immunod...

Metallobiochemistry of the magnesium ion. Characterization of the essential metal-binding site in Escherichia coli ribonuclease H.

Eur. J. Biochem. 219 , 253-60, (1994)

Ribonuclease H (Escherichia coli) contains one strong magnesium-binding site, as determined by metal-titration experiments monitored by high field 1H-NMR and also by direct titration calorimetry. Kine...

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

Bioorg. Med. Chem. Lett. 22(12) , 3988-92, (2012)

We report herein the synthesis of a series of 3-hydroxyquinolin-2(1H)-one derivatives. Esters and amide groups were introduced at position 4 of the basis scaffold and some modulations of the benzenic ...

 核糖核酸酶H英文别名

MFCD00132186