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6,9-二氯-2-甲氧基吖啶

6,9-二氯-2-甲氧基吖啶用途

【用途一】
用作医药中间体。

6,9-二氯-2-甲氧基吖啶名称

[ CAS 号 ]:
86-38-4

[ 中文名 ]:
6,9-二氯-2-甲氧基吖啶

[ 英文名 ]:
6,9-Dichloro-2-methoxyacridine

[英文别名 ]:

Halocrine
3,9-Dichloro-7-methoxyacridine
2-Methoxy-6,9-dichloroacridine
6,9-dichloro-3-methoxyacridine
BIDD:GT0206
Halocrin
6.9-dichloro-2-methoxyacridine
MFCD00005028
EINECS 201-666-7
Acridine,9-dichloro-2-methoxy

6,9-二氯-2-甲氧基吖啶物理化学性质

[ 密度 ]:
1.399 g/cm3

[ 沸点 ]:
444.3ºC at 760 mmHg

[ 熔点 ]:
163-165 °C(lit.)

[ 分子式 ]:
C₁₄H₉Cl₂NO

[ 分子量 ]:
278.13300

[ 闪点 ]:
222.5ºC

[ 精确质量 ]:
277.00600

[ PSA ]:
22.12000

[ LogP ]:
4.70340

[ 折射率 ]:
1.696

[ 储存条件 ]:
2-8°C

6,9-二氯-2-甲氧基吖啶MSDS

6,9-二氯-2-甲氧基吖啶安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H317-H319-H334-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38;R42/43

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

6,9-二氯-2-甲氧基吖啶合成路线

6,9-二氯-2-甲氧基吖啶上下游产品

6,9-二氯-2-甲氧基吖啶上游产品

6,9-二氯-2-甲氧基吖啶下游产品

6,9-二氯-2-甲氧基吖啶制备

【方法一】
由2,4-二氯甲苯经氧化、缩合、酸化、环合、氯化而得。

6,9-二氯-2-甲氧基吖啶海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6,9-二氯-2-甲氧基吖啶文献

N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.

ChemMedChem 9(2) , 305-10, (2014)

Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the de...

Antimalarial acridines: Synthesis, in vitro activity againstP. falciparumand interaction with hematin

Bioorg. Med. Chem. 17(23) , 8032-9, (2009)

Synthesis of new 9-aminoacridines and evaluation of in vitro anti-malarial activity. Inhibitory effect on haem crystallization.

[Preparation and antileukemic activity of quinolizidinylalkyl-derivatives of 4-aminoquinoline and 9-aminoacridine].

Boll. Chim. Farm. 128(6) , 212-5, (1989)

By reacting three quinolizidinylalkylamines with 4,7-dichloroquinoline and 6,9-dichloro-2-methoxyacridine six derivatives of 4-aminoquinoline and 9-aminoacridine were obtained. These compounds, which ...

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