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维生素 K1

维生素 K1用途

Vitamin K1是一种脂溶性,天然存在的维生素。是血液凝固,骨和血管代谢所必须的。

维生素 K1名称

[ CAS 号 ]:
84-80-0

[ 中文名 ]:
植物甲萘醌

[ 英文名 ]:
Vitamin K1

[中文别名 ]:

[英文别名 ]:

KONAKION
Rac-Phytonadione-D7
Phylloquinone-d3
VITAMIN K1 (PHYTONADIONE)
Veda K1
Kephton
Antihemorrhagic vitamin
2-METHYL-3-PHYTYL-1,4-NAPHTHOQUINONE
2',3'-trans-Vitamin K1
AQUAMEPHYTON

维生素 K1生物活性

[ 描述 ]:

Vitamin K1是一种脂溶性,天然存在的维生素。是血液凝固,骨和血管代谢所必须的。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

天然产物 >> 醌类

[体外研究]

叶绿醌(维生素K1)是一种异戊烯化的萘醌,它仅由植物,绿藻和某些蓝藻类物质合成,在那里它作为光系统I中的重要电子载体,并作为蛋白质二硫键形成的电子受体。在人类和其他脊椎动物中,叶绿醌起到维生素(维生素K1)的作用,这是维持血液凝固和骨骼和血管代谢所必需的。来自绿叶蔬菜和植物油的叶绿醌代表了人类维生素K的主要膳食来源[1]。维生素K1处理引起显着的抗增殖作用并诱导Caco-2,HT-29和SW480细胞系中的细胞凋亡,涉及MAPK途径。多胺生物合成的伴随和显着减少发生[2]。

[体内研究]

与减少或不改变叶绿醌摄入量的受试者相比,在随访期间增加维生素K摄入量的受试者患糖尿病的风险降低51％[3]。补充维生素K通过调节成骨细胞和破骨细胞活性来逆转高脂饮食引起的骨质恶化,并防止高脂肪饮食诱导的肥胖小鼠骨质流失[4]。维生素K1在皮肤上的应用已用于抑制色素沉着和消除瘀伤。与伤口收缩,上皮化期,羟脯氨酸含量和拉伸强度等参数相比,局部维生素K1产生的效果显着增强[5]。

[细胞实验]

用递增浓度的维生素K1（10,50,100和200μM）处理Caco-2，HT-29和SW480细胞24小时，48小时和72小时。将MTT加入每个培养皿中并在37℃下孵育2小时。在孵育期结束时，除去培养基。以570nM读取平板[2]。

[动物实验]

大鼠：为了在大鼠中诱导全层伤口，使用切除伤口模型。使用由每组8只大鼠组成的五组。在eucerin碱中制备维生素K霜（1％和2％，w / w）并且每天一次施用于伤口直至完全愈合。愈合的定义是伤口边缘减少（伤口收缩），再上皮化，拉伸强度和羟脯氨酸含量。还进行了组织病理学检查[5]。小鼠：给4周龄C57BL / 6J雄性小鼠喂食10％脂肪正常饮食组或45％大卡高脂饮食组，含或不含200 mg / 1000 g维生素K1（正常饮食+ K1，高 - 脂肪饮食+ K1）和200毫克/ 1000克维生素K2（正常饮食+ K2，高脂肪饮食+ K2）持续12周[4]。

[参考文献]

[1]. Basset GJ, et al. Phylloquinone (Vitamin K1): Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22.

[2]. Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;2015:296721.

[3]. Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96(5):1113-8.

[4]. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13.

[5]. Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46(4):409-12.

[相关活性小分子]

维生素 K1物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
546.4±50.0 °C at 760 mmHg

[ 熔点 ]:
−20 °C(lit.)

[ 分子式 ]:
C₃₁H₄₆O₂

[ 分子量 ]:
450.696

[ 闪点 ]:
200.4±27.1 °C

[ 精确质量 ]:
450.349792

[ PSA ]:
34.14000

[ LogP ]:
12.25

[ 外观性状 ]:
透明强烈的黄色,黏的,油性液体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.511

[ 储存条件 ]:
2-8°C

维生素 K1MSDS

详细MSDS(安全技术说明书)

维生素 K1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5800000

CHEMICAL NAME :: 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-

CAS REGISTRY NUMBER :: 84-80-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C31-H46-O2

MOLECULAR WEIGHT :: 450.77

WISWESSER LINE NOTATION :: L66 BV EVJ C1 D2UY1&3Y1&3Y1&3Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 11429 ug/kg/8D-I

TOXIC EFFECTS :: Blood - eosinophilia Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 121,1421,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >33487 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2808572

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,1339,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,25,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6570 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,653,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4073 No. of Facilities: 394 (estimated) No. of Industries: 4 No. of Occupations: 23 No. of Employees: 26120 (estimated) No. of Female Employees: 15615 (estimated)

维生素 K1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
QJ5800000

[ 海关编码 ]:
2936290090

维生素 K1合成路线

详细合成路线

维生素 K1上下游产品

维生素 K1上游产品

维生素 K1下游产品

维生素 K1制备

1.由甲苯醌还原、乙酰化、与叶绿醇等缩合，再经氧化而得。也可由苜蓿或其他植物体中提取。

2.由邻甲基萘醌与醋酸酐在锌存在下还原、乙酰化生成乙酰化甲萘醌，经水解、缩合得二氢化维生素K1，再经水解、氧化、提纯、精制而得。

3. 烟草：FC，BU，1。

维生素 K1海关

[ 海关编码 ]: 2936290090

维生素 K1文献

Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos.

J. Chromatogr. A. 1412 , 59-66, (2015)

The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. Recently, the zebrafish has been adopted as a valuable animal model system to perform in vivo...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

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