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哌立度酯

哌立度酯用途

Piperidolate是一种抗胆碱剂,作用于大鼠和狗,可抑制乙酰胆碱引起的肠抽筋。

哌立度酯名称

[ CAS 号 ]:
82-98-4

[ 中文名 ]:
哌立度酯

[ 英文名 ]:
Piperidolate

[中文别名 ]:

[英文别名 ]:

Piperidolatum [INN-Latin]
Piperidolato [INN-Spanish]
1-Ethyl-3-piperidinyl diphenylacetate
Diphenylacetic Acid 1-Ethyl-3-piperidyl Ester
Diphenylessigsaeure-(1-ethyl-piperidin-3-yl-ester)
JB 305
diphenylacetic acid-(1-ethyl-[3]piperidyl ester)
EINECS 201-449-7
1-Ethyl-3-piperidyl diphenylacetate
Piperidolate

哌立度酯生物活性

[ 描述 ]:

Piperidolate是一种抗胆碱剂,作用于大鼠和狗,可抑制乙酰胆碱引起的肠抽筋。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[相关活性小分子]

哌立度酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
431.9±45.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₂₅NO₂

[ 分子量 ]:
323.429

[ 闪点 ]:
136.0±19.6 °C

[ 精确质量 ]:
323.188538

[ PSA ]:
29.54000

[ LogP ]:
4.44

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
2-8°C

哌立度酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH2900000

CHEMICAL NAME :: Acetic acid, diphenyl-, 1-ethyl-3-piperidyl ester

CAS REGISTRY NUMBER :: 82-98-4

BEILSTEIN REFERENCE NO. :: 0031110

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H25-N-O2

MOLECULAR WEIGHT :: 323.47

WISWESSER LINE NOTATION :: T6NTJ A2 COVYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Cardiac - pulse rate increase, without fall in BP

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,186,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Cardiac - pulse rate increase, without fall in BP

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,186,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intradermal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 59,149,1938

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Cardiac - pulse rate increase, without fall in BP

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,186,1959

哌立度酯安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933399090

哌立度酯合成路线

详细合成路线

哌立度酯上下游产品

哌立度酯上游产品

哌立度酯下游产品

哌立度酯海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%