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佐芬普利钙

佐芬普利钙用途

Zofenopril Calcium(SQ26991)是抗氧化剂和血管紧张素转化酶(ACE)抑制剂。

佐芬普利钙名称

[ CAS 号 ]:
81938-43-4

[ 中文名 ]:
佐芬普利钙

[ 英文名 ]:
Zofenopril calcium

[中文别名 ]:

[英文别名 ]:

ZOFENOPRIL CALCIUM
MFCD08704648
Zofenopril calcium salt

佐芬普利钙生物活性

[ 描述 ]:

Zofenopril Calcium(SQ26991)是抗氧化剂和血管紧张素转化酶(ACE)抑制剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

研究领域 >> 心血管疾病

[参考文献]

[1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94.

[2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6.

[3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63.

[相关活性小分子]

佐芬普利钙物理化学性质

[ 密度 ]:
1.34 g/cm3

[ 沸点 ]:
646.3ºC at 760 mmHg

[ 熔点 ]:
>250ºC

[ 分子式 ]:
C₂₂H₂₂Ca_0.5NO₄S₂

[ 分子量 ]:
448.58

[ 闪点 ]:
344.7ºC

[ PSA ]:
228.56000

[ LogP ]:
7.80660

[ 外观性状 ]:
白色或发白的结晶粉末

[ 储存条件 ]:
Refrigerator

佐芬普利钙MSDS

佐芬普利钙安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

佐芬普利钙合成路线

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佐芬普利钙文献

Zofenopril plus hydrochlorothiazide fixed combination in the treatment of hypertension and associated clinical conditions.

Cardiovasc. Ther. 27(4) , 275-88, (2009)

Zofenopril, is a highly lipophilic ACE inhibitor, characterized by long-lasting tissue penetration and sustained cardiac ACE inhibition, indicated for the treatment of hypertension and myocardial infa...

Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma.

J. Pharm. Biomed. Anal. 55(3) , 527-32, (2011)

A novel, sensitive and rapid liquid chromatographic-electrospray ionization mass spectrometric method was developed and validated for the determination of zofenopril and its active metabolite zofenopr...

Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits.

J. Cardiovasc. Pharmacol. Ther. 15(4) , 384-92, (2010)

Cough is the most common symptom reported by patients in a primary care setting and is one of the most frequent secondary effects recorded during treatment with angiotensin-converting enzyme (ACE) inh...

更多文献

佐芬普利钙

佐芬普利钙用途

佐芬普利钙名称

佐芬普利钙生物活性

佐芬普利钙物理化学性质

佐芬普利钙MSDS

详细MSDS(安全技术说明书)

佐芬普利钙安全信息

佐芬普利钙合成路线

详细合成路线

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佐芬普利钙上游产品

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佐芬普利钙文献

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