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(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素

(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素用途

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) 是一种vasopressin V1 受体选择性拮抗剂。

(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素名称

[ CAS 号 ]:
73168-24-8

[ 中文名 ]:
(D(CH2)51,TYR(ME)2,ARG8)-VASOPRESSIN

[ 英文名 ]:
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin trifluoroacetate salt

[英文别名 ]:

Avpa
Aavp
MANNING COMPOUND
AVPX

(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素生物活性

[ 描述 ]:

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) 是一种vasopressin V1 受体选择性拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体

研究领域 >> 代谢疾病

[参考文献]

[1]. Arai Y, et al. New topics in vasopressin receptors and approach to novel drugs: research and development of conivaptan hydrochloride (YM087), a drug for the treatment of hyponatremia. J Pharmacol Sci. 2009 Jan;109(1):53-9.

(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素物理化学性质

[ 密度 ]:
1.5 g/cm3

[ 分子式 ]:
C₅₂H₇₄N₁₄O₁₂S₂

[ 分子量 ]:
1151.36

[ 精确质量 ]:
1150.51000

[ PSA ]:
475.01000

[ LogP ]:
3.52940

[ 外观性状 ]:
白色冻干的粉末

[ 折射率 ]:
1.695

(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H332

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素文献

Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid

Prostaglandins Leukot. Essent. Fatty Acids 78(6) , 361-8, (2008)

In the current study, we aimed to determine the cardiovascular effects of arachidonic acid and peripheral mechanisms mediated these effects in normotensive conscious rats. Studies were performed in ma...

Contractile responses of human thyroid arteries to vasopressin.

Life Sci. 93(15) , 525-9, (2013)

In the present study we investigated the intervention of nitric oxide and prostacyclin in the responses to vasopressin of isolated thyroid arteries obtained from multi-organ donors.Paired artery rings...

Selective blockade of oxytocin and vasopressin V(1a) receptors in anaesthetised rats: evidence that activation of oxytocin receptors rather than V(1a) receptors increases sodium excretion.

Nephron. Exp. Nephrol. 117(3) , p21-6, (2011)

Although it is known that moderate-to-high doses of the neurohypophysial hormones oxytocin and vasopressin are natriuretic, doubts remain over the identity of the receptors responsible. To address thi...

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