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1-去氨基青霉胺-2-(O-甲基-酪氨酰)-精氨酸加压素

用途

Dp[Tyr(methyl)2,Arg8]-Vasopressin 是一种非选择性肽精氨酸加压素 Vlb 受体拮抗剂。

名称

[ CAS 号 ]:
67269-08-3

[ 中文名 ]:
1-去氨基青霉胺-2-(O-甲基-酪氨酰)-精氨酸加压素

[ 英文名 ]:
(Deamino-Pen1,Tyr(Me)2, Arg8)-Vasopressin trifluoroacetate salt

[英文别名 ]:

生物活性

[ 描述 ]:

Dp[Tyr(methyl)2,Arg8]-Vasopressin 是一种非选择性肽精氨酸加压素 Vlb 受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体
研究领域 >> 代谢疾病

[参考文献]

[1]. Kamal A. Al-Barazanji. Use of vasopressin receptor antagonist for regulation of acth release. WO1997035602A1.

物理化学性质

[ 密度 ]:
1.49g/cm3

[ 分子式 ]:
C49H70N14O12S2

[ 分子量 ]:
1111.30

[ 精确质量 ]:
1110.47000

[ PSA ]:
475.01000

[ LogP ]:
2.60510

[ 折射率 ]:
1.684

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H332

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems.

Nature 337(6208) , 648-51, (1989)

Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ...

Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study.

Circulation 107(18) , 2313-9, (2003)

Vasodilatory shock is a potentially lethal complication of severe disease in critically ill patients. Currently, catecholamines are the most widely used vasopressor agents to support blood pressure, b...

Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia.

J. Cereb. Blood Flow Metab. 25(8) , 1012-9, (2005)

Brain edema formation is one of the most important mechanisms responsible for brain damage after ischemic stroke. Despite considerable efforts, no specific therapy is available yet. Arginine vasopress...


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相关化合物

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标题:67269-08-3_CAS号:67269-08-3_1-去氨基青霉胺-2-(O-甲基-酪氨酰)-精氨酸加压素 - 化源网 地址:https://www.chemsrc.com/amp/cas/67269-08-3_540215.html