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鸟嘌呤

鸟嘌呤用途

【用途一】
用作抗病毒药物阿昔洛韦中间体
【用途二】
生化研究。
【用途三】
硫鸟嘌呤、开环鸟嘌呤的中间体。

鸟嘌呤名称

[ CAS 号 ]:
73-40-5

[ 中文名 ]:
鸟嘌呤

[ 英文名 ]:
Guanine

[中文别名 ]:

[英文别名 ]:

MFCD00071533
dewpearl
Guanin
2-amino-Hypoxanthine
9H-purin-6-ol, 2-amino-
2-amino-3,7-dihydro-6H-purin-6-one
7H-Purin-6-ol, 2-amino-
Guanine
2-amino-9H-purin-6-ol
Guanie

鸟嘌呤生物活性

[ 描述 ]:

Guanine是核酸(DNA和RNA)的基本组分之一。鸟嘌呤是一种嘌呤衍生物,由具有共轭双键的稠合嘧啶-咪唑环系统组成。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 癌症

[相关活性小分子]

放线菌酮 | 放线菌素D | Alpha-毒伞肽 | 茴香霉素 | SCR7 | CX-5461 | 布拉扑兰 | COH29 | 曲西立滨 | 叶酸 | 氢溴酸常山酮 | RG7800 | N-[4-氟-3-(三氟甲基)苯基]-N'-[5-(4-吡啶基)-1,3,4-噻二唑-2-基]脲 | 腺嘌呤 | 奈达铂

鸟嘌呤物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
561.5±42.0 °C at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₅H₅N₅O

[ 分子量 ]:
151.126

[ 闪点 ]:
293.4±27.9 °C

[ 精确质量 ]:
151.049408

[ PSA ]:
100.45000

[ LogP ]:
-2.03

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
2.047

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
practically insoluble

鸟嘌呤MSDS

鸟嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8260000

CHEMICAL NAME :: Guanine

CAS REGISTRY NUMBER :: 73-40-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H5-N5-O

MOLECULAR WEIGHT :: 151.15

WISWESSER LINE NOTATION :: T56 BM DN FVM INJ HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - ovarian tumors

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

REFERENCE :: NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 19,40,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2576 No. of Facilities: 1778 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4133 (estimated) No. of Female Employees: 3339 (estimated)

鸟嘌呤安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MF8260000

鸟嘌呤合成路线

鸟嘌呤上下游产品

鸟嘌呤上游产品

鸟嘌呤下游产品

鸟嘌呤制备

【方法一】
5-氨基-4-咪唑酰胺与异硫氰酸苯甲酯进行酯化成酯，再与碘甲烷、氨水依次反应制得。

鸟嘌呤文献

Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile.

J. Bacteriol. 197(5) , 819-32, (2015)

Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine monophosphate (c-di-GM...

Electrochemical tuning of oxygen-containing groups on graphene oxides: towards control of the performance for the analysis of biomarkers.

Phys. Chem. Chem. Phys. 16(24) , 12178-82, (2014)

Graphene materials are very popular in the field of biosensing owing to their distinctive characteristics. However, oxygen-containing groups are known to exist intrinsically in graphene-related materi...

Development of an electrochemical surface-enhanced Raman spectroscopy (EC-SERS) aptasensor for direct detection of DNA hybridization.

Phys. Chem. Chem. Phys. 17 , 21356-63, (2015)

Rapid detection of disease biomarkers at the patient point-of-care is essential to timely and effective treatment. The research described herein focuses on the development of an electrochemical surfac...

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鸟嘌呤