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鸟苷

鸟苷用途

Guanosine 是核苷的一种,是由鸟嘌呤与核糖环组成,两者之间由 β-N9-配糖键相连。

鸟苷名称

[ CAS 号 ]:
118-00-3

[ 中文名 ]:
鸟嘌呤核苷

[ 英文名 ]:
Guanosine

[中文别名 ]:

[英文别名 ]:

MFCD00010182
2-amino-Inosine
Guanosine
9-(β-D-Ribofuranosyl)guanine
guanine riboside
Inosine,2-amino
2-Amino-9-(β-D-ribofuranosyl)-9H-purin-6-ol
EINECS 204-227-8
9-β-D-ribofuranosyl-Guanine
vernine

鸟苷生物活性

[ 描述 ]:

Guanosine 是核苷的一种,是由鸟嘌呤与核糖环组成,两者之间由 β-N9-配糖键相连。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

鸟苷可被磷酸化成鸟苷一磷酸(GMP),环鸟苷一磷酸(cGMP),鸟苷二磷酸(GDP)和鸟苷三磷酸(GTP)。这些形式在各种生物化学过程中起重要作用,例如核酸和蛋白质的合成,光合作用,肌肉收缩和细胞内信号转导(cGMP)。

[相关活性小分子]

鸟苷物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 沸点 ]:
756.6±70.0 °C at 760 mmHg

[ 熔点 ]:
240ºC

[ 分子式 ]:
C₁₀H₁₃N₅O₅

[ 分子量 ]:
283.241

[ 闪点 ]:
411.4±35.7 °C

[ 精确质量 ]:
283.091675

[ PSA ]:
159.51000

[ LogP ]:
-3.27

[ 外观性状 ]:
细灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.955

[ 储存条件 ]:
2~8°C

鸟苷MSDS

鸟苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8750000

CHEMICAL NAME :: Guanosine

CAS REGISTRY NUMBER :: 118-00-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H13-N5-O5

MOLECULAR WEIGHT :: 283.28

WISWESSER LINE NOTATION :: T56 BN DN FMYMVJ GUM D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mmol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,52,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9994 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

鸟苷安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MF8750000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29349990

鸟苷合成路线

鸟苷上下游产品

鸟苷上游产品

鸟苷下游产品

鸟苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

鸟苷文献

Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.

Biol. Chem. 395(7-8) , 801-12, (2014)

As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factor...

Hairpin assembly circuit-based fluorescence cooperative amplification strategy for enzyme-free and label-free detection of small molecule.

Talanta 143 , 101-6, (2015)

Here, we developed an enzyme-free, label-free, and sensitive fluorescence cooperative amplification strategy based on a hairpin assembly circuit which coupled catalytic hairpin assembly (CHA) with hyb...

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.

J. Pharmacol. Exp. Ther. 350(3) , 589-604, (2014)

Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for ser...

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鸟苷