2,4-二硝基氟苯

2,4-二硝基氟苯用途

【用途一】
用作医药、农药、染料中间体
【用途二】
本品可制成2,4-二氯氟苯，后者是合成环丙沙星、培氟沙星、二氟沙星等喹喏酮类抗菌药的起始原料。本品也是一种重要的分析试剂，用来鉴定有机化合物中的氨基，尤其是用于检定肽及蛋白质末端氨基酸的氨基。检定时，2，4-二硝基氟苯与肽链的游离氨基作用，生成2，4-二硝基衍生物。将其水解后，末端氨基酸的N-（2，4-二硝基苯基）衍生物常为亮黄色结晶，易与其他氨基酸分离。用该方法结合其他方法，可确定蛋白质或多肽氨基端碳链的结构，称桑格法。本品也用于测定酚和咖啡，以及醛糖分析。

2,4-二硝基氟苯名称

[ CAS 号 ]:
70-34-8

[ 中文名 ]:
2,4-二硝基氟苯

[ 英文名 ]:
1-Fluoro-2,4-dinitrobenzene

[中文别名 ]:

[英文别名 ]:

Sanger reagent
Sanger's Reagent
2,4-DNBF
2,4-Dinitrofluorobenzene
DNFB
fluoro-2,4-dinitrobenzene
Dinitrofluorobenzene
EINECS 200-734-3
Fluorodinitrobenzene
Benzene, 1-fluoro-2,4-dinitro-

2,4-二硝基氟苯物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
296.0±20.0 °C at 760 mmHg

[ 熔点 ]:
25-27 °C(lit.)

[ 分子式 ]:
C₆H₃FN₂O₄

[ 分子量 ]:
186.097

[ 闪点 ]:
132.8±21.8 °C

[ 精确质量 ]:
186.007690

[ PSA ]:
91.64000

[ LogP ]:
1.16

[ 外观性状 ]:
黄色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
库房通风低温干燥,与还原剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
400 mg/L (25 ºC)

2,4-二硝基氟苯MSDS

详细MSDS(安全技术说明书)

2,4-二硝基氟苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ7800000

CHEMICAL NAME :: Benzene, 2,4-dinitro-1-fluoro-

CAS REGISTRY NUMBER :: 70-34-8

BEILSTEIN REFERENCE NO. :: 0398632

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C6-H3-F-N2-O4

MOLECULAR WEIGHT :: 186.11

WISWESSER LINE NOTATION :: WNR BF ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 80 ug/L

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 37,873,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5163 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

2,4-二硝基氟苯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319-H335-H373

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R22;R23/24/25;R33;R34;R40;R42/43

[ 安全声明 (欧洲) ]:
S22-S26-S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 3261 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
CZ7800000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29049085

2,4-二硝基氟苯合成路线

详细合成路线

2,4-二硝基氟苯上下游产品

2,4-二硝基氟苯上游产品

2,4-二硝基氟苯下游产品

2,4-二硝基氟苯制备

1.以2,4-二硝基氯苯与无水氟化钾为原料，经亲核取代反应而得。

2.将无水氟化钾，二甲基亚砜和适量阻聚剂混合，控料加热至120℃，然后加入2,4-二硝基氯苯［各反应物的配比为2,4-二硝基氯苯∶无水氟化钾∶二甲基亚砜∶阻聚剂＝1.0∶1.8∶ 3.4∶0.1（摩尔比)]。维持反应温度在110～120℃（严格控制反应温度，以防爆炸），反应3h：

反应结束后迅速冷却至室温。抽滤除去氟化钾残渣，滤液中加水洗涤，静置后分去水层（可回收二甲基亚砜），油层由水洗涤2次，于2.73kPa下减压蒸馏，收集176～180℃馏分，即为成品2,4-二硝基氟苯。

2,4-二硝基氟苯海关

[ 海关编码 ]: 2904909090

[ 中文概述 ]:
2904909090 其他烃的磺化、硝化、亚硝化衍生物（不论是否卤化）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

2,4-二硝基氟苯文献

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