氟苯
氟苯用途
主要用于制取抗精神病特效药氟哌丁醇等,也用作杀虫剂,并用于塑料和树脂聚合物的鉴定
【用途二】
该品主要用于制抗精神病特效药物氟呱丁醇、达罗呱丁苯、三氟哌啶醇、三氟哌啶苯、五氟利多、喹诺酮类药物-环丙沙星等主要原材料。同时还用于农药杀虫剂和杀卵剂及塑料和树脂聚合物的鉴定。氟苯与γ-氯代丁酰氯缩合可制得γ-氯代对氟苯丁酮,用于合成氟哌啶醇,是丁酰苯类抗精神病药中最常用的药物。
氟苯名称
[ CAS 号 ]:
462-06-6
[ 中文名 ]:
氟苯
[ 英文名 ]:
Fluorobenzene
[中文别名 ]:
[英文别名 ]:
- Monofluorobenzene
- monofluoro boroxine
- 4-fluorobenzene
- EINECS 207-321-7
- Monofluorboroxin
- 1-fluorobenzene
- p-fluorobenzene
- 2-fluorobenzene
- MFCD00000280
- Fluorobenzene
氟苯物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
84.7±9.0 °C at 760 mmHg
[ 熔点 ]:
-42 °C
[ 分子式 ]:
C6H5F
[ 分子量 ]:
96.102
[ 闪点 ]:
-12.8±0.0 °C
[ 精确质量 ]:
96.037529
[ LogP ]:
2.27
[ 外观性状 ]:
无色液体
[ 蒸汽密度 ]:
3.31 (vs air)
[ 蒸汽压 ]:
79.9±0.1 mmHg at 25°C
[ 折射率 ]:
1.473
[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放
[ 稳定性 ]:
Stable. Incompatible with oxidizing agents. Highly flammable - note low flash point.
[ 水溶解性 ]:
INSOLUBLE
氟苯MSDS
氟苯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DA0800000
- CHEMICAL NAME :
- Benzene, fluoro-
- CAS REGISTRY NUMBER :
- 462-06-6
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C6-H5-F
- MOLECULAR WEIGHT :
- 96.11
- WISWESSER LINE NOTATION :
- FR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4399 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 19(9),36,1975
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 26908 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 19(9),36,1975
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 gm/m3/2H
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN. Volume(issue)/page/year: 3,91,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4678 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)
氟苯安全信息
[ 符号 ]:
GHS02, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H319-H412
[ 警示性声明 ]:
P210-P273-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
F:Flammable
[ 风险声明 (欧洲) ]:
R11;R36/37/38
[ 安全声明 (欧洲) ]:
S16-S26-S36-S7-S33-S29-S45-S36/37-S61
[ 危险品运输编码 ]:
UN 2387 3/PG 2
[ WGK德国 ]:
2
[ RTECS号 ]:
DA0800000
[ 包装等级 ]:
II
[ 危险类别 ]:
3
[ 海关编码 ]:
2903999090
氟苯合成路线
氟苯上下游产品
氟苯上游产品
氟苯下游产品
氟苯制备
1.由苯胺经希曼(Schiemann)反应而得。苯胺用31%盐酸成盐后,降温至-8℃,加亚硝酸钠溶液重氮化。将重氮液降温至-10℃,加入氟硼酸溶液,生成溶解度较小的氟硼酸重氮盐,过滤。将氟硼酸重氮苯干燥后进行热解。同时馏出生成的氟苯,馏出液用氢氧化钠溶液洗涤,再用水洗,干燥后进行蒸馏,即得成品,收率约53%。此法消耗大量硼酸,废气多,成本较高。
2.用干燥的亚硝酸钠与苯胺在无水氟化氢中作用,然后使重氮化合物溶液保持40℃以下,收率80%。此法优点是成本低,废气少。
3.三氟醋酐法 以三氟醋酐与环己烷为原料,经加成反应,然后与氟化氢反应生成1,1-二氟环己烷和三氟醋酸;1,1-二氟环己烷再经脱氢、脱氟化氢,即得氟苯。
氟苯海关
[ 海关编码 ]: 2903999090
[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
氟苯文献
Bioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).J. Med. Chem. 48 , 3269-79, (2005)
Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...
QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.Eur. J. Med. Chem. 43 , 714-40, (2008)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...
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区域:上海市奉贤区
价格:
¥88.0/100g
¥258.0/500g
联系人:刘佳
产品详情:氟苯
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区域:上海市浦东新区
价格:
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相关化合物
【氟苯】化源网提供氟苯CAS号462-06-6,氟苯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氟苯上化源网,专业又轻松。>>电脑版:氟苯
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