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4-氟-3-硝基苯胺

4-氟-3-硝基苯胺用途

用于特种染料和功能性染料的原料，如用作毛发染料和液晶染料的合成原料；还可用作医药的合成。

4-氟-3-硝基苯胺名称

[ CAS 号 ]:
364-76-1

[ 中文名 ]:
4-氟-3-硝基苯胺

[ 英文名 ]:
4-Fluoro-3-nitroaniline

[中文别名 ]:

3-硝基-4-氟苯胺

[英文别名 ]:

4-Fluoro-3-nitro-phenylamine
4-Fluoro-3-nitrobenzenamine
3-nitro-4-fluoroaniline
4-Fluoro-3-nitroaniline
EINECS 206-665-5
3-nitro-4-fluoroanailine
4-amino-1-fluoro-2-nitrobenzene
4-fluoro-5-nitroaniline
Benzenamine,4-fluoro-3-nitro
5-amino-2-fluoronitrobenzene

4-氟-3-硝基苯胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
331.3±22.0 °C at 760 mmHg

[ 熔点 ]:
94-96 °C(lit.)

[ 分子式 ]:
C₆H₅FN₂O₂

[ 分子量 ]:
156.115

[ 闪点 ]:
91.1±0.0 °C

[ 精确质量 ]:
156.033508

[ PSA ]:
71.84000

[ LogP ]:
1.27

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.603

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Insoluble

4-氟-3-硝基苯胺MSDS

4-氟-3-硝基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY1700000

CHEMICAL NAME :: Aniline, 4-fluoro-3-nitro-

CAS REGISTRY NUMBER :: 364-76-1

BEILSTEIN REFERENCE NO. :: 2210199

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H5-F-N2-O2

MOLECULAR WEIGHT :: 156.13

WISWESSER LINE NOTATION :: ZR DF CNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1080 mg/kg/90D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - change in clotting factors Blood - changes in erythrocyte (RBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984

4-氟-3-硝基苯胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S36/37-S37/39-S26

[ 危险品运输编码 ]:
UN 1325 4.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
BY1700000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29214210

4-氟-3-硝基苯胺合成路线

4-氟-3-硝基苯胺上下游产品

4-氟-3-硝基苯胺上游产品

4-氟-3-硝基苯胺下游产品

4-氟-3-硝基苯胺海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

4-氟-3-硝基苯胺文献

Inhibition of monoamine oxidase by phenyl azides.

J. Neurochem. 45(3) , 940-5, (1985)

We had previously shown that 4-fluoro-3-nitrophenyl azide (FNPA) is a competitive inhibitor of both types of monoamine oxidase (MAO) in the dark, but it is a preferential photoaffinity label for only ...

Subchronic oral toxicology of 4-fluoro-3-nitroaniline in the rat.

Toxicol. Appl. Pharmacol. 72(3) , 400-5, (1984)

4-Fluoro-3-nitroaniline (4-F-3-NA), an intermediate used in the production of commercial hair dyes, was administered daily for 90 days via po intubation to Charles River CD rats at doses of 40, 120, o...

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