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4-氟苯胺

4-氟苯胺用途

【用途一】
用作医药、染料、农药合成的中间体
【用途二】
用于合成新型含氟医药、农药和染料等。

4-氟苯胺名称

[ CAS 号 ]:
371-40-4

[ 中文名 ]:
4-氟苯胺

[ 英文名 ]:
4-Fluoroaniline

[中文别名 ]:

[英文别名 ]:

P-FLUOROANILINE
4-Fluoroaniline
4-fluoro-anilin
4-fluoro-aniline
MFCD00007829
Benzenamine, 4-fluoro-
4-fluoro-phenylamine
fluoroanilines
p-fluoro-anilin
4-fluorobenzeneamine

4-氟苯胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
188.9±13.0 °C at 760 mmHg

[ 熔点 ]:
-1.9 °C

[ 分子式 ]:
C₆H₆FN

[ 分子量 ]:
111.117

[ 闪点 ]:
73.9±0.0 °C

[ 精确质量 ]:
111.048424

[ PSA ]:
26.02000

[ LogP ]:
1.15

[ 外观性状 ]:
淡黄色至棕色液体

[ 蒸汽压 ]:
0.6±0.4 mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with acids, oxidizing agents.

[ 水溶解性 ]:
33 g/L (20 ºC)

4-氟苯胺MSDS

4-氟苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY1575000

CHEMICAL NAME :: Aniline, 4-fluoro-

CAS REGISTRY NUMBER :: 371-40-4

BEILSTEIN REFERENCE NO. :: 0742030

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C6-H6-F-N

MOLECULAR WEIGHT :: 111.13

WISWESSER LINE NOTATION :: ZR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 417 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 umol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,317,1980

4-氟苯胺安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S37/39

[ 危险品运输编码 ]:
UN 2941 6.1/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
BY1575000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29214210

4-氟苯胺合成路线

4-氟苯胺上下游产品

4-氟苯胺上游产品

4-氟苯胺下游产品

4-氟苯胺制备

1.一步法一步法中较好的工艺是硝基苯法，是经过脱氧、氢化和氟化而得。以PdCl2-V2O5为催化剂，一氧化碳为还原剂，在160℃反应3h，4-氟苯胺产率可达90%，另有10%的副产物苯胺。以PtO2为催化剂，BF3-HF为氟化剂，氢气为还原剂，在42℃下反应12.5h，反应转化率100%，收率达95%。

另外，一步法中还有苯基羟胺法和苯胺法。

2.二步法从不同原料出发合成对氟硝基苯，然后还原、氢化制对氟苯胺。有多种方法：（1）对氯硝基苯氟化法氟化催化剂有以苯乙烯共聚物为基体，接枝四苯基膦或N-烷基氨基吡啶盐、季铵盐类、冠醚及聚乙二醇等。氟化反应使用的溶剂有二甲基亚砜、二甲基甲酰胺、二甲基乙酰胺和环丁砜。

（2）硝基苯氟化法　其中包括：电解氟化法　用硝基苯、氟化氢和季铵盐或Et3N/HF组成的电解液，在室温下通入3-5mA/cm2的电流进行电解氟化。用元素氟或AgF2作氟化剂　将氟气、氮气通入含有硝基苯的甲酸水溶液中，可制得邻、间、对位的混合氟代硝基苯；用AgF2作氟化剂，与硝基苯、氯仿溶液回流18h，得混合氟代硝基苯。

3.对氟硝基苯还原法。

4-氟苯胺海关

[ 海关编码 ]: 29214210

4-氟苯胺文献

Growth of Thin, Anisotropic, π-Conjugated Molecular Films by Stepwise "Click" Assembly of Molecular Building Blocks: Characterizing Reaction Yield, Surface Coverage, and Film Thickness versus Addition Step Number.

J. Am. Chem. Soc. 137 , 8819-28, (2015)

We report the systematic characterization of anisotropic, π-conjugated oligophenyleneimine (OPI) films synthesized using stepwise imine condensation, or "click" chemistry. Film synthesis began with a ...

Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.

Eur. J. Med. Chem. 42 , 1396-402, (2007)

Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry...

The many roles for fluorine in medicinal chemistry.

J. Med. Chem. 51 , 4359-69, (2008)

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