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橙皮素

橙皮素用途

(Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。

橙皮素名称

[ CAS 号 ]:
69097-99-0

[ 中文名 ]:
橙皮素

[ 英文名 ]:
(Rac)-Hesperetin

[英文别名 ]:

3',5,7-Trihydroxy-4'-methoxyflavanone
hesperetine

橙皮素生物活性

[ 描述 ]:

(Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 自噬 >> 自噬

信号通路 >> MAPK/ERK信号通路 >> p38 MAPK

研究领域 >> 神经疾病

[参考文献]

[1]. Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964

[2]. Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059.

[3]. Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301

[4]. Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.

橙皮素物理化学性质

[ 熔点 ]:
227 - 232 °C

[ 分子式 ]:
C₁₆H₁₄O₆

[ 分子量 ]:
302.27900

[ 精确质量 ]:
302.07900

[ PSA ]:
96.22000

[ LogP ]:
2.51850

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
ethanol: soluble50mg/mL, clear to almost clear, colorless to slightly yellow

橙皮素MSDS

详细MSDS(安全技术说明书)

橙皮素安全信息

[ 风险声明 (欧洲) ]:
R36/37/38

[ 危险品运输编码 ]:
NONH for all modes of transport

橙皮素文献

Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.

J. Biochem. Mol. Toxicol. 29(3) , 99-108, (2015)

We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)-induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 1...

Enzyme-assisted extraction enhancing the phenolic release from cauliflower (Brassica oleracea L. var. botrytis) outer leaves.

J. Agric. Food Chem. 62(30) , 7468-76, (2014)

Phenolic compounds are highly present in byproducts from the cauliflower (Brassica oleracea L. var. botrytis) harvest and are thus a valuable source for valorization toward phenolic-rich extracts. In ...

Flavonoid composition and antioxidant activities of Chinese local pummelo (Citrus grandis Osbeck.) varieties.

Food Chem. 161 , 230-8, (2014)

China is one of the most important diversity centres of the genus Citrus L. and is particularly rich in pummelo germplasm. In this study, the flavonoids in the peels and pulps of 28 Chinese local pumm...

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橙皮素