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尿酸

尿酸用途

Uric acid 是一种内源性抗氧化剂,可清除活性氧类化合物 (ROS),包括单线态氧,氧自由基和过氧亚硝酸盐。

尿酸名称

[ CAS 号 ]:
69-93-2

[ 中文名 ]:
尿酸

[ 英文名 ]:
Uric Acid

[中文别名 ]:

[英文别名 ]:

2,6,8-trioxypurine
1H-Purine-2,6,8 (3H)-trione, 7,9-dihydro-
1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-
[14C]-Uric acid
2,6,8-trioxopurine
EINECS 200-720-7
7,9-Dihydro-1H-purine-2,6,8(3H)-trione
1H-Purine-2,6,8-triol
urate
[3H]-Uric acid

尿酸生物活性

[ 描述 ]:

Uric acid 是一种内源性抗氧化剂,可清除活性氧类化合物 (ROS),包括单线态氧,氧自由基和过氧亚硝酸盐。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

尿酸是一种内源性抗氧化剂,可清除活性氧(ROS),包括单线态氧,氧自由基和过氧亚硝酸盐。与未处理的吲哚美辛相比,用吲哚美辛孵育显着增加Caco-2细胞中的丙二醛(MDA)水平。与仅在吲哚美辛存在下生长的那些相比,与吲哚美辛和尿酸一起孵育显着降低了MDA水平。与仅用吲哚美辛孵育的细胞相比,用吲哚美辛和尿酸共处理细胞显着降低ROS水平。用吲哚美辛和尿酸处理的Caco-2细胞中的细胞活力高于仅用吲哚美辛处理的细胞中的细胞活力。尿酸通过其抗氧化活性对吲哚美辛诱导的肠细胞变化具有保护作用[1]。

[体内研究]

当用吲哚美辛治疗的小鼠口服同时施用尿酸时,溃疡区域以尿酸剂量依赖性方式显着降低。吲哚美辛增加回肠中隐窝深度与绒毛高度的比率,而当小鼠同时口服施用尿酸时,该比例显着降低。吲哚美辛的施用还增加了小肠中组织损伤的组织病理学评分,而同时口服施用尿酸的小鼠具有显着较低的组织病理学评分。吲哚美辛诱导的口服尿酸的肠病模型小鼠的回肠丙二醛(MDA)水平也显着低于单独使用吲哚美辛的小鼠的水平[1]。

[细胞实验]

使用人结肠癌细胞（Caco-2）并在Eagle's最小必需培养基中培养，所述培养基补充有10％FBS，1％非必需氨基酸混合物和1％Pen-Strep，在37℃，湿润气氛中，含5％ CO2。在存在或不存在尿酸的情况下，将Caco-2细胞与吲哚美辛一起孵育24或48小时[1]。

[动物实验]

为了评价口服尿酸对NSAID诱导的肠病的影响，给予小鼠在30分钟前口服悬浮于0.5％羧甲基纤维素中的尿酸（2.5,10,25,100或250mg / kg体重），吲哚美辛或载体治疗后12小时。为了评估腹膜内给予肌苷酸加氧嗪酸钾对NSAID诱导的肠病的影响，给小鼠腹腔注射肌苷酸（500 mg / kg体重）加氧嗪酸钾（250 mg / kg体重）24分钟，吲哚美辛或载体治疗后12小时[1]。

[参考文献]

[1]. Yasutake Y, et al. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. J Gastroenterol Hepatol. 2017 Nov;32(11):1839-1845.

[相关活性小分子]

尿酸物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
863ºC at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₅H₄N₄O₃

[ 分子量 ]:
168.110

[ 闪点 ]:
475.7ºC

[ 精确质量 ]:
168.028336

[ PSA ]:
114.37000

[ LogP ]:
-1.08

[ 外观性状 ]:
白色或灰白色粉末或晶体

[ 折射率 ]:
1.721

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with acids, bases, oxidising agents.

[ 水溶解性 ]:
水溶性：实际上不溶；不溶：醇,乙醚

尿酸MSDS

详细MSDS(安全技术说明书)

尿酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7050080

CHEMICAL NAME :: Uric acid

CAS REGISTRY NUMBER :: 69-93-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C5-H4-N4-O3

MOLECULAR WEIGHT :: 168.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5040 mg/kg

SEX/DURATION :: male 4 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mmol/L

REFERENCE :: CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 4,87,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82048 No. of Facilities: 246 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 2320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82048 No. of Facilities: 1210 (estimated) No. of Industries: 5 No. of Occupations: 8 No. of Employees: 17397 (estimated) No. of Female Employees: 12409 (estimated)

尿酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YU7050080

[ 海关编码 ]:
2933990090

尿酸合成路线

详细合成路线

尿酸上下游产品

尿酸上游产品

尿酸下游产品

尿酸制备

1.取干燥鸡粪悬浮于24倍量水中，加入适量氢氧化钙后静置。沉淀完全后分出上清液，沉淀中再加水，用硝酸调节pH值至3，静置至沉淀完全。分出上清液，沉淀物再悬浮在水中，以氢氧化钙调节pH值至12～12.5，过滤后滤液以硝酸调pH值至3，析出物过滤、干燥后即为尿酸粗品。

尿酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

尿酸文献

Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples.

Talanta 143 , 328-34, (2015)

A graphene modified glassy carbon (GR/GCE) sensor has been developed for the determination of aspirin metabolites 2,3- and 2,5-dihydroxybenzoic acids (2,3- and 2,5-DHB). The modified sensor was charac...

Hepatorenal protective effect of Antistax(®) against chemically-induced toxicity.

Pharmacogn. Mag. 11 , S173-81, (2015)

Antioxidant natural products and chemoprevention are considered nowadays as an effective approach against health various disorders and diseases induced by oxidative stress or free radicals.The aim of ...

Facile and controllable one-step fabrication of molecularly imprinted polymer membrane by magnetic field directed self-assembly for electrochemical sensing of glutathione.

Anal. Chim. Acta 886 , 37-47, (2015)

Based on magnetic field directed self-assembly (MDSA) of the ternary Fe3O4@PANI/rGO nanocomposites, a facile and controllable molecularly imprinted electrochemical sensor (MIES) was fabricated through...

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尿酸