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氨己烯酸

氨己烯酸用途

Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物，能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。

氨己烯酸名称

[ CAS 号 ]:
68506-86-5

[ 中文名 ]:
氨己烯酸

[ 英文名 ]:
Vigabatrin

[中文别名 ]:

4-氨基-5-己烯酸

[英文别名 ]:

UNII:GR120KRT6K
vigabatrinum [INN_la]
(±)-γ-Vinyl-GABA
vigabatrine
Vigabatrin
vigabatrinum
4-Aminohex-5-enoic acid
Sabril
vigabatrina
4-Amino-5-hexenoic acid

氨己烯酸生物活性

[ 描述 ]:

Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物,能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[参考文献]

[1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376.

[2]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286.

[3]. Russo, et al. Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity. Behavioural Brain Research (2011), 225(1), 373-376.

[4]. Vigabatrin

[相关活性小分子]

氨己烯酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
277.7±28.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₁₁NO₂

[ 分子量 ]:
129.157

[ 闪点 ]:
121.7±24.0 °C

[ 精确质量 ]:
129.078979

[ PSA ]:
63.32000

[ LogP ]:
-0.10

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.483

[ 储存条件 ]:
2-8℃

氨己烯酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MP7745000

氨己烯酸文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

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