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葫芦素B

葫芦素B用途

葫芦素B (Cucurbitacin B)是一具有抗癌活性的天然化合物。

葫芦素B作用

葫芦素B对人胰腺Y细胞具有深远的体外和体内抗增殖作用。它通过上调PTEN抑制AKT信号激活。葫芦素B是一种有效的HIF-1抑制剂，为其抗癌活性机制提供了新的视角。葫芦素B在A549肺Y细胞中通过STAT3途径抑制抑制增殖并诱导细胞凋亡。

葫芦素B名称

[ CAS 号 ]:
6199-67-3

[ 中文名 ]:
葫芦素 B

[ 英文名 ]:
Cucurbitacin B

[中文别名 ]:

[英文别名 ]:

1,2-Dihydro-a-elaterin
Cucurbitacin B hydrate
1,2-Dihydro-α-elaterin

葫芦素B生物活性

[ 描述 ]:

葫芦素B (Cucurbitacin B)是一具有抗癌活性的天然化合物。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 细胞骨架 >> Integrin

研究领域 >> 癌症

天然产物 >> 萜类化合物和糖苷

[参考文献]

[1]. Shang Y, et al. Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN. Eur Rev Med Pharmacol Sci. 2014;18(21):3297-303.

[2]. Zhang M, et al. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Mol Med Rep. 2014 Dec;10(6):2905-11.

[3]. Gupta P, et al. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget. 2014 Apr 15;5(7):1812-28.

[4]. Guo J, et al. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PLoS One. 2014 Feb 4;9(2):e88140.

[相关活性小分子]

葫芦素B物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
699.3±55.0 °C at 760 mmHg

[ 熔点 ]:
184-186ºC

[ 分子式 ]:
C₃₂H₄₆O₈

[ 分子量 ]:
558.703

[ 闪点 ]:
218.8±25.0 °C

[ 精确质量 ]:
558.319275

[ PSA ]:
138.20000

[ LogP ]:
2.31

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
0.0±5.0 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

葫芦素BMSDS

详细MSDS(安全技术说明书)

葫芦素B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC6190000

CHEMICAL NAME :: 19-Nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-tri one, 2-beta,16-alpha,20,25- tetrahydroxy-9-methyl-, 25-acetate

CAS REGISTRY NUMBER :: 6199-67-3

LAST UPDATED :: 199801

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C32-H46-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 23,605,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 23,605,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2730 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 23,605,1992

葫芦素B安全信息

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
45-24/25

[ 危险品运输编码 ]:
UN 2811 6.1 / PGI

[ RTECS号 ]:
RC6190000

[ 包装等级 ]:
II