葫芦素B
更新时间：2025-08-25 16:01:23
采购访问：218次
| 常用名 | 葫芦素B | CAS号 | 6199-67-3 |
|---|---|---|---|
| 价格 | ￥1188.0/20mg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids; could repress cancer cell progression.IC50 value:Target: anticancer natural compoundin vitro: Cucurbitacin-B inhibited growth and modulated expression of cell-cycle regulators in SHSY5Y cells. At the molecular level, we found that Cucurbitacin-B inhibited AKT signaling activation through up-regulation of PTEN [1]. CuB induced apoptosis of A549 cells in a -concentration-dependent manner, as determined by fluorescence microscopy, flow cytometry and transmission electron microscopy. CuB dose-dependently inhibited lung cancer cell proliferation, with cell cycle inhibition and cyclin B1 downregulation. Apoptosis induced by CuB was shown to be associated with cytochrome c release, B-cell lymphoma 2 downregulation and signal transducer and activator of transcription 3 pathway inhibition [2]. CuB inhibited ITGA6 and ITGB4 (integrin α6 and integrin β4), which are overexpressed in breast cancer. Furthermore, CuB also induced the expression of major ITGB1and ITGB3, which are known to cause integrin-mediated cell death [3]. Cuc B treatment caused DNA double-strand breaks (DSBs) without affecting the signal transducer and activator of transcription 3 (STAT3), the potential molecular target for Cuc B. Cuc B triggers ATM-activated Chk1-Cdc25C-Cdk1, which could be reversed by both ATM siRNA and Chk1 siRNA. Cuc B also triggers ATM-activated p53-14-3-3-σ pathways, which could be reversed by ATM siRNA [4].in vivo: Efficacy of CuB was tested in vivo using two different orthotopic models of breast cancer. MDA-MB-231 and 4T-1 cells were injected orthotopically in the mammary fat pad of female athymic nude mice or BALB/c mice respectively. Our results showed that CuB administration inhibited MDA-MB-231 orthotopic tumors by 55%, and 4T-1 tumors by 40%. The 4T-1 cells represent stage IV breast cancer and form very aggressive tumors [3]. 作用： 葫芦素B对人胰腺Y细胞具有深远的体外和体内抗增殖作用。 它通过上调PTEN抑制AKT信号激活。 葫芦素B是一种有效的HIF-1抑制剂，为其抗癌活性机制提供了新的视角。 葫芦素B在A549肺Y细胞中通过STAT3途径抑制抑制增殖并诱导细胞凋亡。 物理化学性质： CAS号：6199-67-3 常用中文名：葫芦素B 常用英文名：Cucurbitacin B 分子式：C32H46O8 分子量：558.703 密度：1.2±0.1 g/cm3 沸点：699.3±55.0 °C at 760 mmHg 熔点：184-186ºC 闪点：218.8±25.0 °C 储存条件：库房低温,通风,干燥,与食品原料分开存放 |
上海吉至生化科技有限公司
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- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：葫芦素B
- 价格： ￥1188.0/20mg
- 纯度：98.0%
- 备货期：1天
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：cucurbitacin B
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：葫芦素B
- 价格： ￥269.9/5mg ￥720.9/1ml ￥2719.9/100mg ￥849.9/25mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$147/10mM*1mLinDMSO