SU4312

SU4312用途

SU4312 是 (Z)-SU4312 和 (E)-SU4312 的外消旋体。(Z)-SU4312 抑制 PDGFR 和 FLK-1,IC50 分别为 19.4 和 0.8 μM。(E)-SU4312 抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R,IC50 分别为 24.2,5.2,18.5,16.9 和 10.0 μM。

SU4312名称

[ CAS 号 ]:
5812-07-7

[ 英文名 ]:
SU4312

[英文别名 ]:

NSC 86429

SU4312生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白酪氨酸激酶 >> PDGFR

信号通路 >> 蛋白酪氨酸激酶 >> VEGFR

[ 靶点 ]

PDGFR

Flk-1

[体外研究]

受体酪氨酸激酶(RTKs)是细胞信号转导的重要介质。许多rtk已被证明是癌基因产物,在与人类癌症相关的转化过程中起着重要作用[1]。

[参考文献]

[1]. L Sun, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603.

SU4312物理化学性质

[ 密度 ]:
1.219g/cm3

[ 沸点 ]:
497.1ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₁₆N₂O

[ 分子量 ]:
264.32200

[ 闪点 ]:
254.5ºC

[ 精确质量 ]:
264.12600

[ PSA ]:
32.34000

[ LogP ]:
3.38330

[ 外观性状 ]:
红色固体

[ 折射率 ]:
1.683

[ 储存条件 ]:
-20℃

SU4312MSDS

详细MSDS(安全技术说明书)

SU4312安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危险品运输编码 ]:
NONH for all modes of transport

SU4312文献

The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.

Br. J. Pharmacol. 168(5) , 1201-14, (2013)

SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative dis...

Automated image-based phenotypic analysis in zebrafish embryos.

Dev. Dyn. 238(3) , 656-63, (2009)

Presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. Zebrafish embryos are amenable to automation necessary for high-throughput chemical scre...

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