曲麦角碱

曲麦角碱用途

根棒碱是一种天然的棒状麦角生物碱。克拉维是一种D1多巴胺受体和α1-肾上腺素受体激动剂。根棒草碱还具有抗癌和抗菌活性[1][2]。

曲麦角碱名称

[ CAS 号 ]:
548-42-5

[ 中文名 ]:
曲麦角碱

[ 英文名 ]:
AGROCLAVIN

[英文别名 ]:

8,9-didehydro-6,8-dimethyl-ergolin
ERGOLINE,8,9-DIDEHYDRO-6,8-DIMETHYL
6,8-Dimethyl-8,9-didehydro-ergolin
6,8-dimethyl-8,9-didehydro-ergoline
AGROCLAVINE
8,9-didehydro-6,8-dimethylergoline

曲麦角碱生物活性

[ 描述 ]:

根棒碱是一种天然的棒状麦角生物碱。克拉维是一种D1多巴胺受体和α1-肾上腺素受体激动剂。根棒草碱还具有抗癌和抗菌活性[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

信号通路 >> 神经信号通路 >> 多巴胺受体

[ 靶点 ]

D1 Receptor

α1-adrenergic receptor

[参考文献]

[1]. Starec M, et al. Effect of agroclavine on NK activity in vivo under normal and stress conditions in rats. Physiol Res. 2001;50(5):513-9.

[2]. Eich E, et al. Antimicrobial activity of clavines. Arzneimittelforschung. 1985;35(12):1760-2.

曲麦角碱物理化学性质

[ 密度 ]:
1.161g/cm3

[ 沸点 ]:
422.5ºC at 760mmHg

[ 分子式 ]:
C₁₆H₁₈N₂

[ 分子量 ]:
238.32800

[ 闪点 ]:
209.3ºC

[ 精确质量 ]:
238.14700

[ PSA ]:
19.03000

[ LogP ]:
3.00580

[ 折射率 ]:
1.653

曲麦角碱MSDS

详细MSDS(安全技术说明书)

曲麦角碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE6325000

CHEMICAL NAME :: Ergoline, 8,9-didehydro-6,8-dimethyl-

CAS REGISTRY NUMBER :: 548-42-5

BEILSTEIN REFERENCE NO. :: 0024966

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H18-N2

MOLECULAR WEIGHT :: 238.36

WISWESSER LINE NOTATION :: T C6656 1A P GN LM DUTT&&J E1 G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 3-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2 umol/plate

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,1811,1987

曲麦角碱安全信息

[ 海关编码 ]:
2933990090

曲麦角碱上下游产品

曲麦角碱上游产品

曲麦角碱下游产品

曲麦角碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%