2-氨基乙基联苯基硼酸酯

2-氨基乙基联苯基硼酸酯用途

2-Aminoethyl diphenylborinate (2-APB) 是一种细胞通透性 IP3R 抑制剂。2-Aminoethyl diphenylborinate 抑制 store-operated Ca2+ (SOC) 通道,并激活一些 TRP 通道 (V1、V2 和 V3)。

2-氨基乙基联苯基硼酸酯名称

[ CAS 号 ]:
524-95-8

[ 中文名 ]:
二苯基酸

[ 英文名 ]:
2-Aminoethyl Diphenylborinate

[中文别名 ]:

[英文别名 ]:

2-Aminoethoxydiphenylborane
Borinic acid, B,B-diphenyl-, 2-aminoethyl ester
Natural Product Reagent A
2-diphenylboranyloxyethanamine
Diphenylborinic Acid Ethanolamine Ester
EINECS 208-366-5
Diphenylborinic Acid 2-Aminoethyl Ester
2-Aminoethyldiphenylborinate
2-Aminoethyl diphenylborinate
Borinic acid, diphenyl-, 2-aminoethyl ester (9CI)

2-氨基乙基联苯基硼酸酯生物活性

[ 描述 ]:

2-Aminoethyl diphenylborinate (2-APB) 是一种细胞通透性 IP3R 抑制剂。2-Aminoethyl diphenylborinate 抑制 store-operated Ca2+ (SOC) 通道,并激活一些 TRP 通道 (V1、V2 和 V3)。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 感染

[参考文献]

[1]. Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27.

[2]. Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study.

[3]. Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323(2):337-45.

2-氨基乙基联苯基硼酸酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
325.3±34.0 °C at 760 mmHg

[ 熔点 ]:
192-194 °C(lit.)

[ 分子式 ]:
C₁₄H₁₆BNO

[ 分子量 ]:
225.094

[ 闪点 ]:
150.6±25.7 °C

[ 精确质量 ]:
225.132492

[ PSA ]:
35.25000

[ LogP ]:
3.48

[ 外观性状 ]:
白色

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.560

[ 储存条件 ]:
2-8°C

2-氨基乙基联苯基硼酸酯MSDS

2-氨基乙基联苯基硼酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ED6150000

CHEMICAL NAME :: Borinic acid, O-(2-aminoethyl)diphenyl-

CAS REGISTRY NUMBER :: 524-95-8

BEILSTEIN REFERENCE NO. :: 2942273

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H16-B-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01899

2-氨基乙基联苯基硼酸酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
ED6150000

[ 海关编码 ]:
2931900090

2-氨基乙基联苯基硼酸酯合成路线

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2-氨基乙基联苯基硼酸酯上游产品

2-氨基乙基联苯基硼酸酯下游产品

2-氨基乙基联苯基硼酸酯制备

暂无

2-氨基乙基联苯基硼酸酯海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

2-氨基乙基联苯基硼酸酯文献

Inhibition of TRPM7 channels reduces degranulation and release of cytokines in rat bone marrow-derived mast cells.

Int. J. Mol. Sci. 15(7) , 11817-31, (2014)

mast cells play an important role in airway inflammation in asthma. The transient receptor potential melastatin-like 7 (TRPM7) channel is expressed in primary human lung mast cells and plays a critica...

Magnesium modulates the expression levels of calcification-associated factors to inhibit calcification in a time-dependent manner.

Exp. Ther. Med. 9(3) , 1028-1034, (2015)

Vascular calcification, a common complication in patients with chronic kidney disease, involves a variety of mechanisms associated with the regulation of calcification-associated factors. Previous cli...

TRPM7 regulates proliferation and polarisation of macrophages.

J. Cell Sci. 127(21) , 4561-6, (2014)

Ion channels play pivotal roles in regulating important functions of macrophages, such as cytokine and chemokine production, migration, proliferation, phagocytosis and others. In this study, we have i...

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