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1,2-萘醌

1,2-萘醌用途

【用途一】
用于制造染料等，也用于其他有机合成

1,2-萘醌名称

[ CAS 号 ]:
524-42-5

[ 中文名 ]:
1,2-萘醌

[ 英文名 ]:
1,2-NAPHTHOQUINONE

[中文别名 ]:

[英文别名 ]:

EINECS 208-360-2
1,2-Naphthalenedione
MFCD00001698
1,2-NAPHTHOQUINONE

1,2-萘醌物理化学性质

[ 密度 ]:
1.29g/cm3

[ 熔点 ]:
139-142 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₆O₂

[ 分子量 ]:
158.15300

[ 闪点 ]:
117.4ºC

[ 精确质量 ]:
158.03700

[ PSA ]:
34.14000

[ LogP ]:
1.46520

[ 外观性状 ]:
暗棕色粉末

[ 折射率 ]:
1.617

[ 储存条件 ]:
2-8°C

1,2-萘醌MSDS

1,2-萘醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL7000000

CHEMICAL NAME :: 1,2-Naphthoquinone

CAS REGISTRY NUMBER :: 524-42-5

BEILSTEIN REFERENCE NO. :: 0606546

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H6-O2

MOLECULAR WEIGHT :: 158.16

WISWESSER LINE NOTATION :: L66 BVVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,39,1953

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

1,2-萘醌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi,C,F

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QL7000000

[ 海关编码 ]:
2914690090

1,2-萘醌合成路线

1,2-萘醌上下游产品

1,2-萘醌上游产品

1,2-萘醌下游产品

1,2-萘醌制备

暂无

1,2-萘醌海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1,2-萘醌文献

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

A new method and tool for detection and quantification of PM oxidative potential.

Environ. Sci. Pollut. Res. Int. 22 , 12469-78, (2015)

Airborne particulate matter (PM) contains several quinones, which are able to generate reactive oxygen species impacting on cell viability. A method able to detect and quantify PM oxidative potential,...

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

J. Med. Chem. 51 , 1706-18, (2008)

Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune supp...

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