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1-萘酚

1-萘酚用途

1-naphthol是一种激发态质子转移 (ESPT) 荧光分子探针。

1-萘酚名称

[ CAS 号 ]:
90-15-3

[ 中文名 ]:
1-萘酚

[ 英文名 ]:
1-Naphthalenol

[中文别名 ]:

[英文别名 ]:

Ursol ERN
1-Naphthol
1-Naphthalenol
Molisch's reagent
nakotrb
[14C]-1-Naphthol
L66J BQ
Zoba ERN
α-Naphthol
1-hydroxynaphthalene

1-萘酚生物活性

[ 描述 ]:

1-naphthol是一种激发态质子转移 (ESPT) 荧光分子探针。

[ 相关类别 ]:

天然产物 >> 酚类

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Swain J, et al. 1-Naphthol as an ESPT fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media. Phys Chem Chem Phys. 2015 Jul 14;17(26):16752-9.

[相关活性小分子]

1-萘酚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
288.0±0.0 °C at 760 mmHg

[ 熔点 ]:
94-98ºC

[ 分子式 ]:
C₁₀H₈O

[ 分子量 ]:
144.170

[ 闪点 ]:
144.0±10.6 °C

[ 精确质量 ]:
144.057510

[ PSA ]:
20.23000

[ LogP ]:
2.71

[ 外观性状 ]:
淡灰色至棕色固体

[ 蒸汽密度 ]:
4.5 (120 °C, vs air)

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.678

[ 储存条件 ]:
Store in dark!

[ 稳定性 ]:
Stable, but air and light sensitive - store under inert gas. Incompatible with strong bases, strong oxidizing agents.

1-萘酚MSDS

1-萘酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL2800000

CHEMICAL NAME :: 1-Naphthol

CAS REGISTRY NUMBER :: 90-15-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C10-H8-O

MOLECULAR WEIGHT :: 144.18

WISWESSER LINE NOTATION :: L66J BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >420 mg/m3/1H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 134 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg/2W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 90 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 5 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,19,1977 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81692 No. of Facilities: 1281 (estimated) No. of Industries: 20 No. of Occupations: 28 No. of Employees: 12938 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81692 No. of Facilities: 5497 (estimated) No. of Industries: 7 No. of Occupations: 24 No. of Employees: 57255 (estimated) No. of Female Employees: 43248 (estimated)

1-萘酚安全信息

[ 符号 ]:

GHS05, GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H315-H318-H335-H411

[ 警示性声明 ]:
P273-P280-P302 + P352 + P312-P305 + P351 + P338 + P310-P391

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R21/22;R37/38;R41

[ 安全声明 (欧洲) ]:
S2-S22-S26-S37/39

[ 危险品运输编码 ]:
UN 1759

[ WGK德国 ]:
1

[ RTECS号 ]:
QL2800000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2907151000

1-萘酚合成路线

1-萘酚上下游产品

1-萘酚上游产品

1-萘酚下游产品

1-萘酚制备

1. 1-萘酚有多种生产方法，可以分为：α-萘磺酸碱熔法、α-萘胺水解法、四氢萘法。1.α-萘胺水解法α-萘胺以稀硫酸为介质水解得α-萘酚粗品，粗品经分离中和、蒸馏，得成品。2.磺化法精萘用硫酸进行低温磺化得α-萘磺酸，同时副产β-萘磺酸，分离副产物后经中和、碱熔、酸化、再经分离，蒸馏，得成品。原料消耗定额：硫酸（98%）900kg/t、精萘（99.5%）1150kg/t、烧碱（42%）1300kg/t。

2. 水溶液与三氯化铁作用，生气紫色沉淀。

3. 由1-萘磺酸经碱溶液而制得。

1-萘酚海关

[ 海关编码 ]: 2907151000

[ 中文概述 ]:
HS:2907151000 β-萘酚(2-萘酚) 增值税率:17.0% 退税率:9.0% 监管条件:无最低关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2907151000 naphthalen-2-ol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

1-萘酚文献

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.

Nat. Commun. 5 , 5215, (2014)

The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the questi...

Rosmarinic acid attenuates hepatic ischemia and reperfusion injury in rats.

Food Chem. Toxicol. 74 , 270-8, (2015)

Rosmarinic acid (RosmA) demonstrates antioxidant and anti-inflammatory properties. We investigated the effect of RosmA on liver ischemia/reperfusion injury. Rats were submitted to 60 min of ischemia p...

Local administration of stromal cell-derived factor-1 promotes stem cell recruitment and bone regeneration in a rat periodontal bone defect model.

Mater. Sci. Eng. C. Mater. Biol. Appl. 53 , 83-94, (2015)

Stromal cell-derived factor-1 (SDF-1) recruits adult stem/progenitor cells via its specific receptor, C-X-C motif receptor 4 (CXCR4), to promote heart, kidney and tendon regeneration, but little is kn...

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