盐酸脱氧麻黄碱

盐酸脱氧麻黄碱名称

[ CAS 号 ]:
51-57-0

[ 中文名 ]:
盐酸脱氧麻黄碱

[ 英文名 ]:
(+)-Metamfetamine hydrochloride

[中文别名 ]:

去氧麻黄碱盐酸盐

[英文别名 ]:

d-desoxyephedrine hydrochloride
adipex
d-Methylamphetamine hydrochloride
(+)-N,α-dimethylphenethylamine hydrochloride
(+)-Methamphetamine chloride
d-N-Methyl-b-phenylisopropylamine Hydrochloride
(+)METHAMPHETAMINE HYDROCHLORIDE
doxyfed
Hiropon
DOE

盐酸脱氧麻黄碱物理化学性质

[ 沸点 ]:
215.5ºC at 760mmHg

[ 熔点 ]:
166-168ºC

[ 分子式 ]:
C₁₀H₁₆ClN

[ 分子量 ]:
185.694

[ 闪点 ]:
86.8ºC

[ 精确质量 ]:
185.097122

[ PSA ]:
12.03000

[ LogP ]:
3.02990

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

盐酸脱氧麻黄碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH5455000

CHEMICAL NAME :: Phenethylamine, N,alpha-dimethyl-, hydrochloride, (S)-(+)-

CAS REGISTRY NUMBER :: 51-57-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H15-N.Cl-H

MOLECULAR WEIGHT :: 185.72

WISWESSER LINE NOTATION :: 1MY1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10930 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 253,466,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,346,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7560 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,214,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02170

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg female 1-21 day(s) after conception lactating female 19 day(s) post-birth

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis

REFERENCE :: EAGRDS Experimental Aging Research. (Beech Hill Pub. Co., POB 136, Southwest Harbor, ME 04679) V.1- 1975- Volume(issue)/page/year: 5,509,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 792 mg/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1956- Volume(issue)/page/year: 20,625,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA 10158-0012) V.1- 1987- Volume(issue)/page/year: 15,198,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 17 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 19 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6179 No. of Facilities: 28 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1579 (estimated) No. of Female Employees: 1099 (estimated)

盐酸脱氧麻黄碱安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 风险声明 (欧洲) ]:
25

[ 危险品运输编码 ]:
UN 3249

[ RTECS号 ]:
SH5455000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2921499090

盐酸脱氧麻黄碱合成路线

详细合成路线

盐酸脱氧麻黄碱上下游产品

盐酸脱氧麻黄碱上游产品

盐酸脱氧麻黄碱下游产品

盐酸脱氧麻黄碱海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

盐酸脱氧麻黄碱文献

Role of adenosine receptor subtypes in methamphetamine reward and reinforcement.

Neuropharmacology 89 , 265-73, (2014)

The neurobiology of methamphetamine (MA) remains largely unknown despite its high abuse liability. The present series of studies explored the role of adenosine receptors on MA reward and reinforcement...

Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats.

Drug Alcohol Depend. 152 , 15-23, (2015)

Chronic methamphetamine intake has been shown to induce a neuroinflammatory state leading to significant changes in brain functioning including behavioral changes. These changes can persist for years ...

Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach.

PLoS ONE 10 , e0126719, (2015)

Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Meth). In experiments in rats, SB-334867 (SB), an antagonist of orexin receptors (OX1R), at a dose of 1...

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