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氯化苄

氯化苄用途

用作染料中间体及用于单宁、香料、药品等的合成。

氯化苄名称

[ CAS 号 ]:
100-44-7

[ 中文名 ]:
苄基氯

[ 英文名 ]:
Benzyl chloride

[中文别名 ]:

氯化苄

[英文别名 ]:

Benzene, (chloromethyl)-
(Chloromethyl)benzene
phenylmethyl chloride
MFCD00000889
Chloromethylbenzene
toluene, α-chloro-
Benzyl chloride
BENZENE, CHLOROMETHYL-
α-CHLOROTOLUENE
Tolyl chloride

氯化苄物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
179.4±0.0 °C at 760 mmHg

[ 熔点 ]:
-39 °C

[ 分子式 ]:
C₇H₇Cl

[ 分子量 ]:
126.584

[ 闪点 ]:
73.9±0.0 °C

[ 精确质量 ]:
126.023628

[ LogP ]:
2.49

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
4.36 (vs air)

[ 蒸汽压 ]:
1.3±0.3 mmHg at 25°C

[ 折射率 ]:
1.527

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 水溶解性 ]:
0.3 g/L (20 ºC)

氯化苄MSDS

氯化苄毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS8925000

CHEMICAL NAME :: Toluene, alpha-chloro-

CAS REGISTRY NUMBER :: 100-44-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 83

MOLECULAR FORMULA :: C7-H7-Cl

MOLECULAR WEIGHT :: 126.59

WISWESSER LINE NOTATION :: G1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1231 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 ppm/2H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 ppm/2H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 390 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4836 mg/kg/26W-I

TOXIC EFFECTS :: Cardiac - other changes Gastrointestinal - necrotic changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 mg/kg/26W-I

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 ppm/6H/14D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9200 mg/kg/50W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11 ug/kg

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2500 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 3,203,1983 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 5.2 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,49,1982 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,49,1982 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 ppm (5 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,24,1971 OSHA PEL (Gen Indu):8H TWA 1 ppm (5 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 ppm (5 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 ppm (5 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 ppm (5 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (5 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 1 ppm (5 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (5.2 mg/m3) JAN 1993 OEL-DENMARK:STEL 1 ppm (5 mg/m3) JAN 1993 OEL-DENMARK:TWA 1 ppm (5 mg/m3) JAN 1993 OEL-FINLAND:TWA 1 ppm (5 mg/m3);STEL 3 ppm (15 mg/m3) JAN 1993 OEL-FRANCE:TWA 1 ppm (5 mg/m3);STEL 2 ppm (11 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 1 ppm (5 mg/m3);STEL 3 ppm (15 mg/m3);Carcinogen JAN 1993 OEL-GERMANY:TWA 1 ppm (5 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (5 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1 ppm (5 mg/m3) JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 1 ppm (5 mg/m3);STEL 2 ppm (11 mg/m3);Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (5 mg/m3);STEL 2 ppm (10 mg/m3) JAN 1993 OEL-TURKEY:TWA 1 ppm (5 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (3 mg/m3);STEL 2 ppm (6 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (5 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BENZYL CHLORIDE-air:CL 1 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 11600 No. of Facilities: 172 (estimated) No. of Industries: 5 No. of Occupations: 10 No. of Employees: 30504 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 11600 No. of Facilities: 1877 (estimated) No. of Industries: 29 No. of Occupations: 25 No. of Employees: 41075 (estimated) No. of Female Employees: 8440 (estimated)

氯化苄安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H317-H318-H330-H335-H350-H373

[ 警示性声明 ]:
P201-P260-P280-P304 + P340 + P310-P305 + P351 + P338 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R22;R23;R37/38;R41;R45;R48/22

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 1738 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
XS8925000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2903999090

氯化苄合成路线

氯化苄上下游产品

氯化苄上游产品

氯化苄下游产品

氯化苄制备

1.甲苯连续光氯化法将干燥不含铁质的甲苯加到无铁反应器中，在光照下进行高温氯化。然后分馏氯化产物，即得氯化苄，副产氯化氢用水吸收得盐酸，副产α-二氯甲基苯可经水解作用制成苯甲醛。

2.甲苯无光热氯化法甲苯先静置6h以上以除去铁质，再经高位槽送入氯化锅中，以蒸气加热至沸腾后停止加热，通入氯气进行氯化，连续反应制得的氯化苄通过底部溢流管冷却后进入贮槽。氯化苄的制备主要由甲苯氯化而得。目前国内外主要有两种方法：光氯化法和无光热氯化法。从工艺操作来分，两种方法又各有间歇操作和连续操作两种。从反应器结构来分，连续操作又可分为水平连续操作和垂直连续操作两种。由于甲苯连续光氯化法具有小批量生产容易上马，反应速度比无光热氯化法快的优点，国内较多厂家采用此工艺。一般采用小型水平串联连续式反应器组。将干燥不含铁质的甲苯加入玻璃氯化瓶中，加热至110℃，使液体缓缓沸腾，按氯气与甲苯质量比为1∶2.5在日光灯照射下通入氯气，于110～120℃进行高温氯化反应至终点。蒸馏回收未反应的甲苯，收集160～180℃馏分即为粗品氯化苄。再经常压分馏，收集176～182℃馏分，即得到氯化苄成品。
甲苯无光热氯化法则一般采用大型垂直连续式搪瓷反应釜。此外，甲苯在催化剂过氧化物存在下与氯化亚硫反应，或在氯化锌催化下苯环氯甲基化等，均可制得氯化苄。

3.制法：

于装有温度计、回流冷凝器(顶部连一氯化钙干燥音，干燥管连接氯化氢和氯气吸收装置)、通气导管的反应瓶中，加入甲苯(2)92g(1.0mol)，几粒沸石，油浴加热至沸。用一只200W的灯泡照射^①，通入经浓硫酸干燥的氯气(直接通到反应瓶底部)，在微沸状态下连续通氯直至瓶内温度升至156℃时，停止通氯。常压蒸馏，先回收未反应的甲苯，再收集165～185℃的馏分。重新蒸馏，收集178～182℃的馏分。得氯化苄(1)^①90g,收率70%。注：①也可用日光灯或石英灯照射，该反应为自由基型反应。②也可用甲基在过氧化戊存在下与氯化亚砜反应来制备，或由苯的氯甲基化等反应来制备。

氯化苄海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

氯化苄文献

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氯化苄