匹立尼酸
匹立尼酸用途
匹立尼酸名称
[ CAS 号 ]:
50892-23-4
[ 中文名 ]:
匹立尼酸
[ 英文名 ]:
Wy-14643
[中文别名 ]:
[英文别名 ]:
- WY-14643
- Wyeth 14643
- T6N CNJ BS1VQ DMR B1 C1& FG
- pirinixic acid
- MFCD00191335
- WY14643
匹立尼酸生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
PPARα:0.63 μM (EC50)
PPARγ:32 μM (EC50)
[体外研究]
[体内研究]
[细胞实验]
[动物实验]
[参考文献]
[相关活性小分子]
匹立尼酸物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
514.4±50.0 °C at 760 mmHg
[ 熔点 ]:
155°C
[ 分子式 ]:
C14H14ClN3O2S
[ 分子量 ]:
323.798
[ 闪点 ]:
264.9±30.1 °C
[ 精确质量 ]:
323.049530
[ PSA ]:
100.41000
[ LogP ]:
4.92
[ 外观性状 ]:
固体;White to Light yellow powder to crystal
[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C
[ 折射率 ]:
1.658
[ 储存条件 ]:
Store at RT
匹立尼酸MSDS
匹立尼酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AG2915000
- CHEMICAL NAME :
- Acetic acid, ((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-
- CAS REGISTRY NUMBER :
- 50892-23-4
- BEILSTEIN REFERENCE NO. :
- 0759945
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 23
- MOLECULAR FORMULA :
- C14-H14-Cl-N3-O2-S
- MOLECULAR WEIGHT :
- 323.82
- WISWESSER LINE NOTATION :
- T6N CNJ BS1VQ DG FMR B1 C1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 330 mg/kg/8W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 126 mg/kg/21D-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1092 mg/kg/26W-C
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of endocrine pancreas Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1545 mg/kg/2Y-C
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - changes in platelet count Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22 gm/kg/1Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37 gm/kg/62W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 46 gm/kg/65W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27 gm/kg/64W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29 gm/kg/69W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- Morphological transformation
- TYPE OF TEST :
- Unscheduled DNA synthesis
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 85 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996
匹立尼酸安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H315-H319-H335-H350
[ 警示性声明 ]:
P201-P261-P305 + P351 + P338-P308 + P313
[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T
[ 风险声明 (欧洲) ]:
45-22-36/37/38
[ 安全声明 (欧洲) ]:
S26;S45;S53;S36/S37/S39
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
AG2915000
[ 海关编码 ]:
2933599090
匹立尼酸合成路线
匹立尼酸上下游产品
匹立尼酸上游产品
匹立尼酸下游产品
匹立尼酸海关
[ 海关编码 ]: 2933599090
[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
匹立尼酸文献
Lipids Health Dis. 12 , 11, (2013)
Peroxisome proliferator activated receptor alpha (PPARα) ameliorates ethanol induced hepatic steatohepatitis. However, its role in alcoholic liver fibrosis has not been fully clarified. The aim of thi...
Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.J. Clin. Invest. 123(3) , 1229-40, (2013)
Exogenous dietary fat can induce obesity and promote diabetes, but endogenous fat production is not thought to affect skeletal muscle insulin resistance, an antecedent of metabolic disease. Unexpected...
Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.Hepatology 60(6) , 1929-41, (2014)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder caused by abnormal lipid metabolisms, such as reduced hepatic fatty acid oxidation (FAO), but intracellular control o...
推荐生产厂家/供应商:
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥659.0/50mg
¥539.0/1g
¥2159.0/250mg
¥需询单/1g
联系人:李先生
产品详情:WY-14643 (Pirinixic Acid)
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥291.9/250mg
¥698.9/1g
¥2333.9/5g
¥需询单/1g
联系人:阿拉丁李高志
产品详情:[4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥592.0/250mg
¥1361.0/1g
¥656.6/50mg
¥需询单/1ml
联系人:夏言
产品详情:[Perfemiker]WY-14643 (Pirinixic Acid),≥98%
公司名:武汉敬康恩生物医药科技有限公司
区域:武汉市东西湖区
价格:
¥1.0/1g
联系人:周经理
产品详情:匹立尼酸
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相关化合物
【匹立尼酸】化源网提供匹立尼酸CAS号50892-23-4,匹立尼酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询匹立尼酸上化源网,专业又轻松。>>电脑版:匹立尼酸
标题:匹立尼酸_MSDS_用途_密度_匹立尼酸CAS号【50892-23-4】_化源网 地址:https://www.chemsrc.com/amp/cas/50892-23-4_1194838.html