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熊果苷

熊果苷用途

β-熊果苷是一种糖苷,可抑制酪氨酸酶,阻止黑色素生成。

熊果苷作用

【用途一】
医药上用作利尿剂、泌尿系统抗感染药，也用作彩色摄影显影稳定剂，在化妆品中用于增白、祛斑、护发等
【用途二】
生化研究。化妆品工业。

熊果苷名称

[ CAS 号 ]:
497-76-7

[ 中文名 ]:
熊果苷

[ 英文名 ]:
Arbutin

[中文别名 ]:

[英文别名 ]:

Ericolin)
4-Hydroxyphenyl β-D-glucopyranoside
Uresol
Hydroquinone-β-D-glucoside
EINECS 207-850-3
Hydroquinone-b-D-glucopyranoside
p-Hydroxyphenyl β-D-glucopyranoside
Hydroquinone-β-D-glucopyranoside
Hydroquinoneβ-D-glucopyranoside
hydroquinone O-beta-D-glucopyranoside

熊果苷生物活性

[ 描述 ]:

β-熊果苷是一种糖苷,可抑制酪氨酸酶,阻止黑色素生成。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶

天然产物 >> 酚类

研究领域 >> 其他

[参考文献]

[1]. Arbutin, From Wikipedia

[相关活性小分子]

熊果苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
561.6±50.0 °C at 760 mmHg

[ 熔点 ]:
195-198 °C

[ 分子式 ]:
C₁₂H₁₆O₇

[ 分子量 ]:
272.251

[ 闪点 ]:
293.4±30.1 °C

[ 精确质量 ]:
272.089600

[ PSA ]:
119.61000

[ LogP ]:
-1.35

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.650

[ 储存条件 ]:
存放于惰性气体之中;避免空气,湿气 (吸湿)

[ 水溶解性 ]:
10-15 g/100 mL at 20 ºC

熊果苷MSDS

详细MSDS(安全技术说明书)

熊果苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE8863000

CHEMICAL NAME :: Arbutin

CAS REGISTRY NUMBER :: 497-76-7

BEILSTEIN REFERENCE NO. :: 0089673

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H16-O7

MOLECULAR WEIGHT :: 272.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13600 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating female 20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,282,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1290 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 995 (estimated) No. of Female Employees: 745 (estimated)

熊果苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CE8863000

[ 海关编码 ]:
29389090

熊果苷上下游产品

熊果苷上游产品

熊果苷下游产品

熊果苷制备

1.存在于虎耳草科植物虎耳草[Saxifrifra stolonifiera(L.)Meerb.]的全草，杜鹃花科植物越橘(Vaccinicum vitis-idaea L.)的叶等许多植物中。亦可化学合成。

2.将熊果叶粉碎冲洗干净后加水煮沸，抽提2次，合并水抽提液并减压浓缩至糖浆状，再加入甲醇使其溶解，滤除甲醇不溶物，减压回收甲醇后即为熊果苷粗品。若在水中以活性炭脱色、过滤、重结晶，即得熊果苷纯品。

熊果苷海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

熊果苷文献

Change in chemical constituents and free radical-scavenging activity during Pear (Pyrus pyrifolia) cultivar fruit development.

Biosci. Biotechnol. Biochem. 79(2) , 260-70, (2015)

Changes in chemical constituent contents and DPPH radical-scavenging activity in fruits of pear (Pyrus pyrifolia) cultivars during the development were investigated. The fruits of seven cultivars (cv....

Cellular Anti-Melanogenic Effects of a Euryale ferox Seed Extract Ethyl Acetate Fraction via the Lysosomal Degradation Machinery.

Int. J. Mol. Sci. 16 , 9217-35, (2015)

The aim of this study was to investigate the effect of ethyl acetate fraction of Euryale ferox seed extracts (Efse-EA) on melanogenesis in immortalized mouse melanocyte cell line, melan-a. Efse-EA sho...

Avocado Proanthocyanidins as a Source of Tyrosinase Inhibitors: Structure Characterization, Inhibitory Activity, and Mechanism.

J. Agric. Food Chem. 63 , 7381-7, (2015)

Proanthocyanidins were purified from avocado (Persea americana) fruit, and their structures were analyzed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS)...

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熊果苷