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2-甲基-1,3-二氧戊环

2-甲基-1,3-二氧戊环用途

用于制聚合物材料。

2-甲基-1,3-二氧戊环名称

[ CAS 号 ]:
497-26-7

[ 中文名 ]:
2-甲基-1,3-二氧戊环

[ 英文名 ]:
1,3-Dioxolane,2-methyl-

[中文别名 ]:

[英文别名 ]:

2-METHYL-1,3-DIOXOLANE
Acetaldehyde Ethylene Acetal
EINECS 207-841-4
MFCD00003210

2-甲基-1,3-二氧戊环物理化学性质

[ 密度 ]:
0.99

[ 沸点 ]:
82-83 °C(lit.)

[ 分子式 ]:
C₄H₈O₂

[ 分子量 ]:
88.10510

[ 闪点 ]:
28 °F

[ 精确质量 ]:
88.05240

[ PSA ]:
18.46000

[ LogP ]:
0.37920

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
341.95mmHg at 25°C

[ 折射率 ]:
n20/D 1.398(lit.)

[ 储存条件 ]:
Flammables area

[ 水溶解性 ]:
水溶性：完全混溶

2-甲基-1,3-二氧戊环MSDS

2-甲基-1,3-二氧戊环毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JI3509000

CHEMICAL NAME :: 1,3-Dioxolane, 2-methyl-

CAS REGISTRY NUMBER :: 497-26-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C4-H8-O2

MOLECULAR WEIGHT :: 88.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,797,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,797,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - antipsychotic

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(8),89,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 gm/m3

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(11),94,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(11),94,1974

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 gm/m3

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(11),94,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7600 mg/kg/22W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 42(3),12,1977

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/m3/6H/22W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Kidney, Ureter, Bladder - proteinuria Blood - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(11),94,1974

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/m3/6H/17W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Liver - changes in liver weight

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(11),94,1974

2-甲基-1,3-二氧戊环安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,Xi

[ 风险声明 (欧洲) ]:
11-36

[ 安全声明 (欧洲) ]:
S16-S26

[ 危险品运输编码 ]:
UN 1993 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
JI3509000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

2-甲基-1,3-二氧戊环合成路线

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2-甲基-1,3-二氧戊环文献

Muscarinic cholinergic receptors in the embryonic chick heart: interaction of agonist, receptor, and guanine nucleotides studied by an improved assay for direct binding of the muscarinic agonist [3H]cismethyldioxolane.

Mol. Pharmacol. 32(1) , 230-40, (1987)

Muscarinic agonist binding has been studied by the indirect method of competition between binding of agonist and 3H-antagonist. Studies of 3H-agonist binding have either been complicated by high level...

Potency ratio for the inhibition of 3H-QNB and 3H-cis-methyldioxolane binding predicts agonist or antagonist activity on muscarinic receptors.

Methods Find. Exp. Clin. Pharmacol. 10(10) , 619-21, (1988)

3H-Quinuclidinyl benzylate (3H-QNB) and 3H-cis-methyldioxolane (3H-CD) binding to cholinergic muscarinic receptors have been carried out on the same membrane preparation from the rat brain cortex. Inh...

Binding studies with [3H]cis-methyldioxolane in different tissues. Under certain conditions [3H]cis-methyldioxolane labels preferentially but not exclusively agonist high affinity states of muscarinic M2 receptors.

Naunyn Schmiedebergs Arch. Pharmacol. 335(4) , 372-7, (1987)

Special conditions--tricine buffer containing Ca2+ and Mg2+, 22 degrees C (TCM)--allow to label a much higher proportion of muscarinic receptors by [3H]cis-methyldioxolane (CD) than hitherto described...

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