(-)-双环甲硫脲

(-)-双环甲硫脲用途

荷包牡丹甲酰亚胺是一种有效的GABA(a)受体阻滞剂。二瓜氨酸甲酰化物改变膜的性质和燃烧模式。荷包牡丹碱甲酰亚胺降低了Apamin敏感的超极化后,而Apamin是一种从蜂毒中分离出来的毒素,用于阻断小电导Ca2+激活的K+通道。荷包牡丹碱甲碘化物通过阻断apamin敏感的Ca2+激活的K+电流促进突发放电[1]。

(-)-双环甲硫脲名称

[ CAS 号 ]:
40709-69-1

[ 中文名 ]:
(-)-双环甲硫脲

[ 英文名 ]:
Bicuculline methiodide

[英文别名 ]:

bicuculine methiodide

(-)-双环甲硫脲生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[体外研究]

二次甲基二瓜氨酸(30μM)促进 N个-甲基-天-天冬氨酸 (纳米达)刺激,促进多巴胺神经元的爆发性放电[1] 研究表明,反奖励中枢外侧缰核(左b)的簇状放电是抑郁症发生的充分条件。左心室神经元常分为三类：沉默型(无声),强直放电型(补烧)簇状放电型(连发射击)[2]

[参考文献]

[1]. Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231(1):13-6.

[2]. Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554(7692): 317-322.

(-)-双环甲硫脲物理化学性质

[ 分子式 ]:
C₂₁H₂₀INO₆

[ 分子量 ]:
509.29

[ 精确质量 ]:
509.03400

[ PSA ]:
63.22000

[ 储存条件 ]:
室温

(-)-双环甲硫脲安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

(-)-双环甲硫脲合成路线

详细合成路线

(-)-双环甲硫脲上下游产品

(-)-双环甲硫脲上游产品

(-)-双环甲硫脲下游产品

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