16,16-Dimethyl prostaglandin E2

16,16-Dimethyl prostaglandin E2用途

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) 是一种具有口服活性的脊椎动物造血干细胞 (HSCs) 稳态关键调节剂。16,16-Dimethyl prostaglandin E2 可以通过 EP2/EP4 起作用,并与 Wnt 途径相互作用。

16,16-Dimethyl prostaglandin E2名称

[ CAS 号 ]:
39746-25-3

[ 中文名 ]:
16,16-二甲基前列腺素 E2

[ 英文名 ]:
16,16-Dimethyl prostaglandin E2

[英文别名 ]:

16,16-Dimethyl prostaglandin E2生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

研究领域 >> 炎症/免疫

[ 靶点 ]

EP2

EP4

[体内研究]

16,16-二甲基前列腺素E2(16,16-二甲基PGE2；10微克/千克；i.p.；每12小时；连续8天)拯救Tpl2IMF-KO小鼠恶化的DSS结肠炎表型,并恢复上皮增殖和结构[2]。动物模型：Tpl2IMF-KO小鼠[2]剂量：10μg/kg给药：IP；每12小时一次；连续8天结果：挽救了DSS结肠炎加重的表型,恢复了上皮细胞增殖和结构。

[参考文献]

[1]. Hagedorn EJ, et al. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. xp Cell Res. 2014 Dec 10;329(2):220-6.

[2]. Roulis M, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67.

16,16-Dimethyl prostaglandin E2物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
541.3±50.0 °C at 760 mmHg

[ 熔点 ]:
-85.6ºC

[ 分子式 ]:
C₂₂H₃₆O₅

[ 分子量 ]:
380.518

[ 闪点 ]:
295.2±26.6 °C

[ 精确质量 ]:
380.256287

[ PSA ]:
94.83000

[ LogP ]:
2.57

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.551

16,16-Dimethyl prostaglandin E2毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK7894000

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11-alpha,13E,15R)-

CAS REGISTRY NUMBER :: 39746-25-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H36-O5

MOLECULAR WEIGHT :: 380.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 ug/kg

SEX/DURATION :: female 34 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 6,349,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 64 ug/kg

SEX/DURATION :: female 6 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,167,1977

16,16-Dimethyl prostaglandin E2安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,Xn,Xi

[ 风险声明 (欧洲) ]:
11-20/21/22-36/37/38-67-66-36

[ 安全声明 (欧洲) ]:
16-26-36

[ 危险品运输编码 ]:
UN 1231 3/PG 2

16,16-Dimethyl prostaglandin E2合成路线

详细合成路线

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16,16-Dimethyl prostaglandin E2文献

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Several clinical trials are exploring therapeutic effect of human CD34(+) cells in ischemic diseases, including myocardial infarction. Unfortunately, most of the cells die few days after delivery. Her...

Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control.

Circulation 110(16) , 2326-32, (2004)

In the preterm newborn, a patent ductus arteriosus is in large part a result of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2). PGE2 acts through 3 G protein-coupled recep...

Prostanoids regulate angiogenesis acting primarily on IP and EP4 receptors.

Microvasc. Res. 101 , 127-34, (2015)

Angiogenesis is regulated by numerous activators and inhibitors, including prostanoids. Although many studies have identified their roles in inflammation, regulatory functions of prostanoids in angiog...

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