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香草酸甲酯

香草酸甲酯用途

Methyl vanillate 是枳椇属植物中的提取物,是Wnt/β-catenin信号通路活化剂[1]。苯甲酸酯,是香草酸的甲酯。它具有抗氧化作用。植物代谢物。

香草酸甲酯名称

[ CAS 号 ]:
3943-74-6

[ 中文名 ]:
香草酸甲酯

[ 英文名 ]:
Methyl vanillate

[中文别名 ]:

[英文别名 ]:

4-Hydroxy-3-methoxybenzoic Acid Methyl Ester
Methyl 4-hydroxy-3-methoxybenzoate
MFCD00008438
Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester
Vanillic Acid Methyl Ester
Vanillic acid, methyl ester (8CI)
Methyl vanillate
EINECS 223-525-9

香草酸甲酯生物活性

[ 描述 ]:

Methyl vanillate 是枳椇属植物中的提取物,是Wnt/β-catenin信号通路活化剂[1]。苯甲酸酯,是香草酸的甲酯。它具有抗氧化作用。植物代谢物。

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号

天然产物 >> 酸和醛

研究领域 >> 炎症/免疫

[ 靶点 ]

Wnt/β-catenin[1]

[体外研究]

香草酸甲酯(0-100μM)增加颅骨成骨细胞中β-连环蛋白的表达和核转位。香草酸甲酯剂量依赖性地提高颅骨成骨细胞的ALP活性[1]。

[参考文献]

[1]. Cha PH, et al. Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. PLoS One. 2014 Jan 22;9(1):e85546.

[相关活性小分子]

香草酸甲酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
286.0±0.0 °C at 760 mmHg

[ 熔点 ]:
64-67 °C(lit.)

[ 分子式 ]:
C₉H₁₀O₄

[ 分子量 ]:
182.173

[ 闪点 ]:
120.2±15.8 °C

[ 精确质量 ]:
182.057907

[ PSA ]:
55.76000

[ LogP ]:
1.54

[ 外观性状 ]:
淡黄色至米色粉末和颗粒

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
Room temperature.

香草酸甲酯MSDS

香草酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2430000

CHEMICAL NAME :: Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester

CAS REGISTRY NUMBER :: 3943-74-6

BEILSTEIN REFERENCE NO. :: 1369113

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H10-O4

MOLECULAR WEIGHT :: 182.19

WISWESSER LINE NOTATION :: 1OVR DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06782

香草酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DH2430000

[ 海关编码 ]:
2918990090

香草酸甲酯合成路线

香草酸甲酯上下游产品

香草酸甲酯上游产品

香草酸甲酯下游产品

香草酸甲酯海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

香草酸甲酯文献

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.

Bioorg. Med. Chem. 18 , 3823-33, (2010)

A series of 33 novel divanillates and trivanillates were synthesized and found to possess promising cytostatic rather than cytotoxic properties. Several compounds under study decreased by >50% the act...

The influence of heat on the aroma of cloudberries (rubus Chamaemorus l.).

Z. Lebensm. Unters. Forsch. 163(1) , 25-30, (1977)

The qualitative and quantitative differences between the volatiles of fresh and heated cloudberries have been evaluated and the significance of the differences calculated. 14 new cloudberry volatiles ...

Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.

J. Nat. Prod. 69 , 662-4, (2006)

Three linear sesquiterpene lactones, anthecotulide (1), hydroxyanthecotulide (2), and acetoxyanthecotulide (3), were isolated from the aerial parts of Anthemis auriculata. Five known flavonoids, tarax...

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