<生产厂家价格>

井冈霉素

井冈霉素用途

Validamycin A 是一种氨基糖苷类农用抗生素。Validamycin A 能抑制黄曲霉的生长, 其 MIC 值为 1 μg/mL。Validamycin A 是一种可逆的酪氨酸酶抑制剂,其 Ki 值为 5.893 mM。

井冈霉素名称

[ CAS 号 ]:
37248-47-8

[ 中文名 ]:
井冈霉素

[ 英文名 ]:
Validamycin

[中文别名 ]:

井岗霉素

[英文别名 ]:

valimon
Validamycin A
validamycin
Validamycin
Jinganmycin A
SOLACOL
MYCIN
VALIDAMYCIN A
VALDIDAMYCIN
VALIDACIN

井冈霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶

[ 靶点 ]

Ki: 5.893 mM (tyrosinase)[2]

[体外研究]

validamycina(0.5-1μg/mL；18h)抑制黄曲霉生长和分生孢子萌发延迟[1]。缬霉素A对人支气管上皮细胞无细胞毒性[1]。缬霉素A直接与酪氨酸酶活性部位的几个残基结合,包括HIS85、HIS244、GLU256、HIS259和ASN260[1]。细胞增殖试验[1]细胞株：黄曲霉ATCC204304浓度：0.5μg/mL,1μg/mL孵育时间：18h结果：抑制黄曲霉生长。

[参考文献]

[1]. Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415.

[2]. Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23.

井冈霉素物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
813.7±65.0 °C at 760 mmHg

[ 熔点 ]:
130-135ºC

[ 分子式 ]:
C₂₀H₃₅NO₁₃

[ 分子量 ]:
497.491

[ 闪点 ]:
445.9±34.3 °C

[ 精确质量 ]:
497.210846

[ PSA ]:
253.02000

[ LogP ]:
-5.43

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±6.6 mmHg at 25°C

[ 折射率 ]:
1.689

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

井冈霉素MSDS

详细MSDS(安全技术说明书)

井冈霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM7540000

CHEMICAL NAME :: D-chiro-Inositol, 1,5,6-trideoxy-3-O-beta-D-glucopyranosyl-5-(hydroxyme thyl)-1-((4,5,6- trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino) -, (1S-(1-alpha,4-alpha,5-beta, 6-alpha))-

CAS REGISTRY NUMBER :: 37248-47-8

LAST UPDATED :: 199606

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C20-H35-N-O13

MOLECULAR WEIGHT :: 497.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (15),28,1973

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S29,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (40),32,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,229,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >13 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (15),28,1973

井冈霉素安全信息

[ 危害码 (欧洲) ]:
T+

井冈霉素合成路线

详细合成路线

井冈霉素上下游产品

井冈霉素上游产品

井冈霉素下游产品

井冈霉素制备

由吸水链霉素井冈变种发酵提取制成。工艺流程：砂土管—母斜面—茄子瓶—种子罐—发酵罐—放罐