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2,2'-联吡啶

2,2'-联吡啶用途

2,2'-Bipyridine 是以藻红菌素 (CAEs) 和collismycins (COLs) 为代表的生物活性天然产物的独特分子支架。2,2'-Bipyridine 广泛用作许多螯合配体的核心结构,在催化中心的排列中起桥梁作用。

2,2'-联吡啶名称

[ CAS 号 ]:
366-18-7

[ 中文名 ]:
2,2'-联吡啶

[ 英文名 ]:
2,2'-Bipyridine

[中文别名 ]:

[英文别名 ]:

bipyridine
2-(2-pyridyl)pyridine
α,α'-dipyridine
EINECS 206-674-4
2,2’-Bipyridyl
dipyridyl
2,2'-Bipyridin
2,2-BIPYRIDINE
2-pyridin-2-ylpyridine
2,2′-bipyridine

2,2'-联吡啶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Chen D, et al. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J Ind Microbiol Biotechnol. 2019;46(3-4):459-468.

2,2'-联吡啶物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
272.5±0.0 °C at 760 mmHg

[ 熔点 ]:
70-73 °C(lit.)

[ 分子式 ]:
C₁₀H₈N₂

[ 分子量 ]:
156.184

[ 闪点 ]:
107.2±12.0 °C

[ 精确质量 ]:
156.068741

[ PSA ]:
25.78000

[ LogP ]:
1.28

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.581

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, most common metals. May be light sensitive.

[ 水溶解性 ]:
5.5 g/L 22 ºC

2,2'-联吡啶MSDS

2,2'-联吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW1750000

CHEMICAL NAME :: 2,2'-Bipyridine

CAS REGISTRY NUMBER :: 366-18-7

BEILSTEIN REFERENCE NO. :: 0113089

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H8-N2

MOLECULAR WEIGHT :: 156.20

WISWESSER LINE NOTATION :: T6NJ B- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes in urine composition Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 131 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8000 mg/kg/40W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 14500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,223,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84441 No. of Facilities: 141 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 708 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84441 No. of Facilities: 461 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 3684 (estimated) No. of Female Employees: 886 (estimated)

2,2'-联吡啶安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311

[ 警示性声明 ]:
P280-P301 + P310-P312

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S36/37-S45-S36/37/39-S26

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DW1750000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29333999

2,2'-联吡啶合成路线

2,2'-联吡啶上下游产品

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2,2'-联吡啶下游产品

2,2'-联吡啶制备

1.由吡啶与三氯化铁反应而得。取70g无水吡啶与13g无水三氯化铁混合，在封管中于300℃加热反应约35h。冷却后，反应物固化为红黑色结晶，打开封管，用少量热水洗出固体物的红黑色溶液。用乙醚萃取除去油状不纯物。用碳酸氢钠中和后，用蒸汽加热除去过量的吡啶。然后将混合物调成强碱性，用蒸汽蒸出2,2'-联吡啶。蒸出物酸化后蒸发浓缩，再加氢氧化钠，用乙醚提取，除去乙醚得粗品。粗品用乙来重结晶、活性炭脱色即得纯品。另外，由α-甲基吡啶[109-06-8]与高锰酸钾反应，经提纯处理也可制得该品。

2.将无水吡啶与无水三氯化铁混合，加热反应，冷却固化得红黑色结晶。用蒸汽加热除去过量的吡啶。蒸出2,2'-联吡啶。再加氢氧化钠用乙醚作溶剂，除去乙醚，得粗品。用无铁活性炭脱色，过滤，得白色叶片状结晶，即为纯品2,2'-联吡啶。

2,2'-联吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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