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2-氯吡啶

2-氯吡啶用途

【用途一】
用于医药、杀虫剂、有机合成
【用途二】
防霉剂如吡硫霉净的中间体。
【用途三】
医药、杀菌剂等，有机合成的中间体。

2-氯吡啶名称

[ CAS 号 ]:
109-09-1

[ 中文名 ]:
2-氯吡啶

[ 英文名 ]:
2-Chloropyridine

[中文别名 ]:

[英文别名 ]:

Pyridine,2-chloro-
α-Chloropyridine
2-Cl-pyridine
2-Chloro-pyridine
o-Chloropyridine
2-Chloropyridine
T6NJ BG
EINECS 203-646-3
MFCD00006228
Pyridine, 2-chloro-

2-氯吡啶物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
170.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-46 °C

[ 分子式 ]:
C₅H₄ClN

[ 分子量 ]:
113.545

[ 闪点 ]:
65.0±0.0 °C

[ 精确质量 ]:
113.003227

[ PSA ]:
12.89000

[ LogP ]:
1.40

[ 外观性状 ]:
透明无色至淡黄色液体

[ 蒸汽压 ]:
2.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.530

[ 储存条件 ]:
库房通风低温干燥,与氧化剂,食品分开储运

[ 水溶解性 ]:
27 g/L (20 ºC)

2-氯吡啶MSDS

2-氯吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5950000

CHEMICAL NAME :: Pyridine, 2-chloro-

CAS REGISTRY NUMBER :: 109-09-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C5-H4-Cl-N

MOLECULAR WEIGHT :: 113.55

WISWESSER LINE NOTATION :: T6NJ BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppm/4H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - fatty liver degeneration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - fatty liver degeneration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 1980 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 301,57,1993

2-氯吡啶安全信息

[ 符号 ]:

GHS05, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H310 + H330-H315-H318-H335-H373-H410

[ 警示性声明 ]:
P260-P280-P302 + P352 + P310-P304 + P340 + P310-P305 + P351 + P338 + P310-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 2822 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
US5950000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933399090

2-氯吡啶合成路线

2-氯吡啶上下游产品

2-氯吡啶上游产品

2-氯吡啶下游产品

2-氯吡啶制备

用2-氨基吡啶经桑德曼尔反应制得。

2-氯吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氯吡啶文献

Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents

Bioorg. Med. Chem. 18 , 7836-41, (2010)

Antiproliferative assay results indicated that compounds 6o and 6u exhibited the most potent activity against gastric cancer cell SGC-7901, which was more potent than the positive control. Especially,...

Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents.

Bioorg. Med. Chem. Lett. 20 , 4163-4167, (2010)

A series of novel 2-chloro-pyridine derivatives containing flavone, chrome or dihydropyrazole moieties as potential telomerase inhibitors were synthesized. The bioassay tests showed that compounds 6e ...

Detailed compositional characterization of plastic waste pyrolysis oil by comprehensive two-dimensional gas-chromatography coupled to multiple detectors.

J. Chromatogr. A. 1359 , 237-46, (2014)

The detailed compositional characterization of plastic waste pyrolysis oil was performed with comprehensive two-dimensional GC (GC×GC) coupled to four different detectors: a flame ionization detector ...

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