2-苯基-1,4-苯醌

2-苯基-1,4-苯醌用途

TFIIH Modulator-19 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.

2-苯基-1,4-苯醌名称

[ CAS 号 ]:
363-03-1

[ 中文名 ]:
苯基-P-苯醌

[ 英文名 ]:
TFIIH Modulator19

[英文别名 ]:

PHENYL-P-BENZOQUINONE
2-phenylcyclohexa-2,5-diene-1,4-dione
EINECS 206-654-5

2-苯基-1,4-苯醌物理化学性质

[ 密度 ]:
1.1336 (rough estimate)

[ 沸点 ]:
278.14°C (rough estimate)

[ 熔点 ]:
111-115 °C

[ 分子式 ]:
C₁₂H₈O₂

[ 分子量 ]:
184.19100

[ 精确质量 ]:
184.05200

[ PSA ]:
34.14000

[ LogP ]:
1.77800

[ 外观性状 ]:
Chunks and Powder | Yellow-brown

[ 折射率 ]:
1.6086 (estimate)

[ 储存条件 ]:
室温，干燥

2-苯基-1,4-苯醌MSDS

详细MSDS(安全技术说明书)

2-苯基-1,4-苯醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK6650000

CHEMICAL NAME :: p-Benzoquinone, phenyl-

CAS REGISTRY NUMBER :: 363-03-1

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C12-H8-O2

MOLECULAR WEIGHT :: 184.20

WISWESSER LINE NOTATION :: L6V DVJ XR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 5 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,1,1991

2-苯基-1,4-苯醌安全信息

[ 危害码 (欧洲) ]:
Xn;Xi

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38;R42/43

[ 安全声明 (欧洲) ]:
S26;S36;S37/S39

[ RTECS号 ]:
DK6650000

[ 海关编码 ]:
2914399090

2-苯基-1,4-苯醌合成路线

详细合成路线

2-苯基-1,4-苯醌上下游产品

2-苯基-1,4-苯醌上游产品

2-苯基-1,4-苯醌下游产品

2-苯基-1,4-苯醌海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%