2,5-二羟基联苯

2,5-二羟基联苯用途

TFIIH Modulator-12 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.

2,5-二羟基联苯名称

[ CAS 号 ]:
1079-21-6

[ 中文名 ]:
2-苯基氢醌

[ 英文名 ]:
2,5-Biphenyldiol

[中文别名 ]:

[英文别名 ]:

2,5-Dihydroxy-biphenyl
2,5-Biphenyldiol
EINECS 214-091-1
[1,1'-Biphenyl]-2,5-diol
4-hydroxy-2-phenylphenol
Biphenyl-2,5-diol
2-phenylhydroquinone
PHENYLHYDROQUINONE
MFCD00002342
2,5-Dihydroxybiphenyl

2,5-二羟基联苯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
383.0±30.0 °C at 760 mmHg

[ 熔点 ]:
98-100 °C(lit.)

[ 分子式 ]:
C₁₂H₁₀O₂

[ 分子量 ]:
186.207

[ 闪点 ]:
192.3±19.2 °C

[ 精确质量 ]:
186.068085

[ PSA ]:
40.46000

[ LogP ]:
2.09

[ 外观性状 ]:
白色至灰色-褐色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

2,5-二羟基联苯MSDS

2,5-二羟基联苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV4550000

CHEMICAL NAME :: 2,5-Biphenyldiol

CAS REGISTRY NUMBER :: 1079-21-6

BEILSTEIN REFERENCE NO. :: 1949429

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C12-H10-O2

MOLECULAR WEIGHT :: 186.22

WISWESSER LINE NOTATION :: QR DQ BR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1010 mg/m3/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/m3/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Endocrine - changes in spleen weight Endocrine - changes in thymus weight

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,1,1991

2,5-二羟基联苯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DV4550000

[ 海关编码 ]:
2907299090

2,5-二羟基联苯合成路线

2,5-二羟基联苯海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

2,5-二羟基联苯文献

Cytotoxic effects of phenyl-hydroquinone and some hydroquinones on isolated rat hepatocytes.

Biochem. Pharmacol. 44(6) , 1059-65, (1992)

The cytotoxic effects of phenyl-hydroquinone (PHQ) and some other hydroquinones on freshly isolated rat hepatocytes were investigated. Addition of PHQ (0.5 or 0.75 mM) to the hepatocytes elicited dose...

Tuning surface hydrophilicity/hydrophobicity of hydrocarbon proton exchange membranes (PEMs).

J. Colloid. Interface Sci. 466 , 168-77, (2016)

The effect of annealing on the surface hydrophilicity of various representative classes of hydrocarbon-based proton exchange membranes (PEMs) is investigated. In all cases, a more hydrophilic membrane...

Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis.

Carcinogenesis 12(1) , 145-9, (1991)

o-Phenylphenol (OPP) and its sodium salt sodium ortho-phenylphenate (NaOPP) are broad spectrum fungicides and antibacterial agents. Both are urinary bladder and renal carcinogens in the Fischer 344 ra...

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