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L-环丝氨酸

L-环丝氨酸用途

L-cycloserine作用于大肠杆菌和各种动物大脑, 不可逆地抑制GABA 5'-磷酸吡哆醛氨基转移酶, 这种作用具有时间依赖性, 导致了γ-氨基丁酸 (GABA) 含量增高, GABA在体内抑制性神经递质。

L-环丝氨酸名称

[ CAS 号 ]:
339-72-0

[ 中文名 ]:
3-氟-4-(三氟甲基)苯甲醛

[ 英文名 ]:
L-Cycloserine

[中文别名 ]:

L-环丝氨酸

[英文别名 ]:

1-bromo-2,3,5,6-tetradeuterio-4-fluoro-benzene
1-(5-(Hydroxymethyl)pyrimidin-2-yl)piperidin-4-ol
d4-4-bromofluorobenzene
cycloserine
1-Bromo-4-fluorobenzene-d4
4-amino-isoxazolidin-3-one
D-4-amino-3-isoxazolidone
4-fluoro-2,3,5,6-tetradeuterobromobenzene
L-CYCLOSERINE
MFCD00064324

L-环丝氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

天然产物 >> 其他

研究领域 >> 神经疾病

[相关活性小分子]

L-环丝氨酸物理化学性质

[ 密度 ]:
1.278

[ 熔点 ]:
147ºC

[ 分子式 ]:
C₃H₆N₂O₂

[ 分子量 ]:
102.09200

[ 精确质量 ]:
102.04300

[ PSA ]:
64.35000

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
2-8°C

L-环丝氨酸MSDS

详细MSDS(安全技术说明书)

L-环丝氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY2976000

CHEMICAL NAME :: 3-Isoxazolidinone, 4-amino-, (L)-

CAS REGISTRY NUMBER :: 339-72-0

BEILSTEIN REFERENCE NO. :: 0080799

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C3-H6-N2-O2

MOLECULAR WEIGHT :: 102.11

WISWESSER LINE NOTATION :: T5OMVTJ DZ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 25,411,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 25,411,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 25,411,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2492 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 25,411,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1889 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 25,411,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1071 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 25,411,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 25,411,1986

L-环丝氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R5

[ 安全声明 (欧洲) ]:
38-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
NY2976000

[ 海关编码 ]:
2934999090

L-环丝氨酸海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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