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DL-肾上腺素(肾上腺素)

DL-肾上腺素(肾上腺素)用途

DL-Epinephrine是肾上腺素的消旋体。L-Epinephrine是由肾上腺髓质分泌的激素。它是α-adrenergic和β-adrenergic受体激动剂。

DL-肾上腺素(肾上腺素)名称

[ CAS 号 ]:
329-65-7

[ 中文名 ]:
消旋肾上腺素

[ 英文名 ]:
DL-Adrenalin

[中文别名 ]:

[英文别名 ]:

EINECS 206-347-6
4-[1-Hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
4-(1-Hydroxy-2-(methylamino)ethyl)benzene-1,2-diol
dl-Epinephrine
Epinephrine dl-
adrenaline
rac Epinephrine
MFCD00063027
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
(±)-Epinephrine

DL-肾上腺素(肾上腺素)生物活性

[ 描述 ]:

DL-Epinephrine是肾上腺素的消旋体。L-Epinephrine是由肾上腺髓质分泌的激素。它是α-adrenergic和β-adrenergic受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[体内研究]

与未处理的对照眼相比,将12微升体积的1％L-肾上腺素硼酸盐溶液施用于12只猴子的一只眼睛的角膜上,分别使通过虹膜和睫状体的血流减少59％和20％[ 1]。肾上腺素是一种直接作用的拟交感神经药α-肾上腺素能和β-肾上腺素能激动剂,具有环腺苷一磷酸介导的,复杂的,对许多靶器官的双向药理作用[2]。在年轻成年大鼠中,肾上腺素的内源性释放促进了对于时间相关事件的稳定记忆形成。肾上腺素通过增加调节记忆所需的血糖水平来增强年轻成年大鼠的记忆[3]。肾上腺素是心肺复苏(CPR)期间用于逆转心脏骤停的主要药物。肾上腺素通过α-1-肾上腺素能受体激动剂作用增加CPR期间的动脉血压和冠状动脉灌注[4]。

[动物实验]

大鼠：对于免疫组织化学实验，大鼠接受培训后立即皮下注射生理盐水（0.9％），葡萄糖（250 mg / kg）或肾上腺素（0.1 mg / kg），然后返回保持笼[3] 。

[参考文献]

[1]. Alm A, et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980 May;19(5):487-91.

[2]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44.

[3]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27.

[4]. Callaway CW, et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42.

[相关活性小分子]

DL-肾上腺素(肾上腺素)物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
413.1±40.0 °C at 760 mmHg

[ 熔点 ]:
197 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₁₃NO₃

[ 分子量 ]:
183.204

[ 闪点 ]:
207.9±17.9 °C

[ 精确质量 ]:
183.089539

[ PSA ]:
72.72000

[ LogP ]:
-0.63

[ 外观性状 ]:
无气味的淡棕色或几乎白色晶体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.608

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Sparingly soluble

DL-肾上腺素(肾上腺素)MSDS

详细MSDS(安全技术说明书)

DL-肾上腺素(肾上腺素)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO2975000

CHEMICAL NAME :: Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (+-)-

CAS REGISTRY NUMBER :: 329-65-7

BEILSTEIN REFERENCE NO. :: 2212160

LAST UPDATED :: 199709

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C9-H13-N-O3

MOLECULAR WEIGHT :: 183.23

WISWESSER LINE NOTATION :: QR BQ DYQ1M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,501,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,57,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,57,1948 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4149 No. of Facilities: 399 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 8846 (estimated) No. of Female Employees: 6257 (estimated)

DL-肾上腺素(肾上腺素)安全信息

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R24;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
DO2975000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2922509090

DL-肾上腺素(肾上腺素)合成路线

详细合成路线

DL-肾上腺素(肾上腺素)上下游产品

DL-肾上腺素(肾上腺素)上游产品

DL-肾上腺素(肾上腺素)下游产品

DL-肾上腺素(肾上腺素)海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%