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L-谷氨酸二叔丁酯盐酸盐

L-谷氨酸二叔丁酯盐酸盐用途

H-Glu(OtBu)-OtBu盐酸盐是一种谷氨酸衍生物,可用于P物质拮抗剂的合成[1]。

L-谷氨酸二叔丁酯盐酸盐名称

[ CAS 号 ]:
32677-01-3

[ 中文名 ]:
L-谷氨酸二叔丁酯盐酸盐

[ 英文名 ]:
H-Glu(OtBu)-OtBu.HCl

[中文别名 ]:

H-谷氨酸(OTBU)-OTBU盐酸盐

[英文别名 ]:

H-Glu(OtBu)-OtBu·HCl
H-Glu(OtBu)-OtBuï¿½ï¿½HCl
L-glutamic acid di-t-butyl ester hydrochloride
MFCD00058003
Di-tert-butyl L-glutamate hydrochloride (1:1)
H-Glu(OtBu)-OtBu,HCl
H-L-Glu(OtBu)-OtBu*HCl
L-Glutamic acid di-tert
L-Glutamic Acid di-Tert-Butyl Ester Hydrochloride
H-Glu(OtBu)-OtBu.HCl

L-谷氨酸二叔丁酯盐酸盐生物活性

[ 描述 ]:

H-Glu(OtBu)-OtBu盐酸盐是一种谷氨酸衍生物,可用于P物质拮抗剂的合成[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 神经激肽受体

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体

[ 靶点 ]

Substance P[1]

[参考文献]

[1]. Manolopoulou A, et al. Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids. Int J Pept Protein Res. 1993 Apr;41(4):411-4.

L-谷氨酸二叔丁酯盐酸盐物理化学性质

[ 密度 ]:
1.02g/cm3

[ 沸点 ]:
311.1ºC at 760 mmHg

[ 熔点 ]:
60 to 75ºC

[ 分子式 ]:
C₁₃H₂₆ClNO₄

[ 分子量 ]:
295.803

[ 闪点 ]:
78.1ºC

[ 精确质量 ]:
295.155029

[ PSA ]:
78.62000

[ LogP ]:
3.27960

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
−20°C

L-谷氨酸二叔丁酯盐酸盐MSDS

L-谷氨酸二叔丁酯盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0880000

CHEMICAL NAME :: L-Glutamic acid, bis(1,1-dimethylethyl)ester, hydrochloride

CAS REGISTRY NUMBER :: 32677-01-3

LAST UPDATED :: 198703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H25-N-O4.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 7,275,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 7,275,1985

L-谷氨酸二叔丁酯盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MA0880000

L-谷氨酸二叔丁酯盐酸盐合成路线

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L-谷氨酸二叔丁酯盐酸盐文献

Synthesis and biological activity of analogues of the C-terminal hexapeptide of substance P with modifications at glutaminyl and methioninyl residues. Structure-activity studies.

Int. J. Pept. Protein Res. 40 , 395-400, (1992)

Analogues of [Orn6]-SP6-11 have been synthesized in which the methionyl residue is replaced by glutamine gamma-carboxamide substituted derivatives. These analogues where tested in three in vitro prepa...

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Convulsant properties of L-glutamic acid di-tert butyl ester.

Neurobehav. Toxicol. Teratol. 7 , 275-278, (1985)

Glutamic acid di-tert butyl ester (GTBE) was found to have a pronounced convulsant effect in mice and rats, producing recurrent clonic convulsions combined with postural and respiratory disturbances i...

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