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2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮

用途

BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。

名称

[ CAS 号 ]:
2854-32-2

[ 中文名 ]:
2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基)-1-吗啉乙酮

[ 英文名 ]:
BML-190

[中文别名 ]:

[英文别名 ]:

Indomethacin morpholinamide
Lopac-I-151
BML-190
Tocris-1383
2-Methyl-5-methoxy-3-indolyl-essigsaeure-amid
IMMA
Indomethacin morpholinylamide

生物活性

[ 描述 ]:

BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体

研究领域 >> 癌症

[参考文献]

[1]. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences (

[2]. Klegeris, Andis; Bissonnette, Christopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786.

[3]. New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
586.7±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₃H₂₃ClN₂O₄

[ 分子量 ]:
426.893

[ 闪点 ]:
308.6±30.1 °C

[ 精确质量 ]:
426.134644

[ PSA ]:
60.77000

[ LogP ]:
2.99

[ 外观性状 ]:
solid | off-white

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: >20mg/mL

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD9930000

CHEMICAL NAME :: Morpholine, 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl) acetyl)-

CAS REGISTRY NUMBER :: 2854-32-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H23-Cl-N2-O4

MOLECULAR WEIGHT :: 426.93

WISWESSER LINE NOTATION :: T56 BNJ BVR DG& C1 GO1 D1V- AT6N DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,309,1975

安全信息

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

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海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%